Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.42 |
| ▸ | CTSA | P10619 | 7/20 | 0.42 |
| ▸ | POLQ | O75417 | 2/20 | 0.42 |
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 3/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | GNAI2 | P04899 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | HCK | P08631 | 1/20 | 0.41 |
| ▸ | ROS1 | P08922 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30017216 | 1.00 | DHODH (0.42) | DHODHCTSAPOLQHTR5AAURKA | |
| SCHEMBL22717310 | 0.91 | POLQ (0.46) | DHODHCTSAPOLQHTR5AAURKA | |
| SCHEMBL30017759 | 0.90 | POLQ (0.43) | CTSAPOLQHTR5AAURKAAURKB | |
| SCHEMBL24770167 | 0.90 | POLQ (0.43) | CTSAPOLQHTR5AAURKAAURKB | |
| SCHEMBL29694637 | 0.83 | POLQ (0.48) | CTSAPOLQHTR5ALRRK2GABRA1 | |
| SCHEMBL22717429 | 0.83 | POLQ (0.48) | CTSAPOLQHTR5ALRRK2GABRA1 | |
| SCHEMBL29575480 | 0.83 | POLQ (0.48) | CTSAPOLQHTR5ALRRK2GABRA1 | |
| SCHEMBL24501582 | 0.80 | GRM7 (0.47) | POLQ | |
| SCHEMBL30640253 | 0.80 | GRM7 (0.47) | POLQ | |
| SCHEMBL24769909 | 0.80 | POLQ (0.62) | POLQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117794927-A | O-linked thiadiazolyl compounds as inhibitors of DNA polymerase theta | 伊迪亚生物科学有限公司 | 2024-03-29 | — | — | CN | disclosed |
| WO-2022259204-A1 | O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-12-15 | — | — | WO | disclosed |