Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | CCR5 | P51681 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24771347 | 0.81 | ALDH1A1 (0.55) | ALDH1A1TDP1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL24771293 | 0.80 | KDM4E (0.49) | ALDH1A1TDP1KDM4ESMN1; SMN2HTT | |
| SCHEMBL4591716 | 0.79 | ALDH1A1 (0.67) | ALDH1A1KDM4ESMN1; SMN2HTTMEN1 | |
| SCHEMBL5428662 | 0.79 | OPRM1 (0.53) | ALDH1A1TDP1KDM4ESMN1; SMN2OPRM1 | |
| SCHEMBL24771575 | 0.79 | KMT2A (0.53) | ALDH1A1TDP1KDM4ESMN1; SMN2HTT | |
| SCHEMBL24770944 | 0.78 | KDM4E (0.65) | ALDH1A1TDP1KDM4ESMN1; SMN2HTT | |
| SCHEMBL29943598 | 0.78 | ALDH1A1 (0.59) | ALDH1A1TDP1KDM4ESMN1; SMN2HTT | |
| SCHEMBL23301276 | 0.78 | ALDH1A1 (0.59) | ALDH1A1TDP1KDM4ESMN1; SMN2HTT | |
| SCHEMBL3755882 | 0.77 | FAAH (0.55) | ALDH1A1TDP1OPRM1 | |
| SCHEMBL28868539 | 0.76 | ALDH1A1 (0.45) | ALDH1A1TDP1KDM4ESMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117500785-A | Azetidinyl-containing carboxylic acid compounds for the treatment of neurodegenerative diseases | 细胞基因公司 | 2024-02-02 | — | — | CN | disclosed |
| US-20230028747-A1 | Carboxylic Acid Containing Azetidinyl Compounds for the Treatment of Neurodegenerative Diseases | CELGENE CORPORATION (US) | 2023-01-26 | — | — | US | disclosed |
| WO-2022266162-A1 | AZETIDINYL COMPOUNDS COMPRISING A CARBOXYLIC ACID GROUP FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | CELGENE CORPORATION (US) | 2022-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230028747-A1 | Carboxylic Acid Containing Azetidinyl Compounds for the Treatment of Neurodegenerative Diseases | S1PR5, LPAR5, S1PR2 | ALDH1A1 1161/4885TDP1 1735/4885KDM4E 383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.