Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL369673 | 0.84 | CRHR1 (0.34) | — | |
| SCHEMBL7598386 | 0.81 | KDM4E (0.30) | — | |
| SCHEMBL4825084 | 0.70 | KDM4E (0.32) | — | |
| SCHEMBL3261534 | 0.68 | CRHR1 (0.36) | MEN1KMT2A | |
| SCHEMBL11787506 | 0.67 | KDM4E (0.33) | — | |
| SCHEMBL20391235 | 0.67 | CRHR1 (0.31) | — | |
| SCHEMBL11590615 | 0.66 | CRHR1 (0.33) | — | |
| Tromethamine SCHEMBL5176238 | 0.66 | MEN1 (0.42) | MEN1LMNAKMT2A | |
| SCHEMBL5935165 | 0.66 | HSP90AA1 (0.33) | — | |
| SCHEMBL24728110 | 0.66 | CRHR1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2535371-A1 | CROSS-LINKING AGENT FOR CROSS-LINKABLE ELASTOMERS AND APPLICATION THEREOF | Nippon Kasei Chemical Co., Ltd. (JP) | 2012-12-19 | — | — | EP | disclosed |
| EP-2373704-A1 | FLUOROELASTOMER, CURABLE COMPOSITION AND CURED RUBBER ARTICLE | Daikin Industries, Ltd. (JP) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010101304-A1 | FLUOROELASTOMER, CURABLE COMPOSITION AND CURED RUBBER ARTICLE | DAIKIN INDUSTRIES, LTD. (JP) | 2010-09-10 | — | — | WO | disclosed |