Sugi Predict

Sugi Predict / Compounds / SCHEMBL2477801

SCHEMBL2477801

SCHEMBL2477801

COc1c[c]ccc1N1CCC(O)C1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SMPD3 Q9NY59 2/20 0.42
▸ MCHR1 Q99705 2/20 0.40
▸ SUV39H2 Q9H5I1 2/20 0.37
▸ AR P10275 1/20 0.35
▸ NTSR1 P30989 3/20 0.35
▸ ITGB2 P05107 1/20 0.35
▸ ICAM1 P05362 1/20 0.35
▸ ITGAL P20701 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ RAD52 P43351 1/20 0.34
▸ ABCB1 P08183 1/20 0.34
▸ ABCG2 Q9UNQ0 1/20 0.34
▸ TBK1 Q9UHD2 1/20 0.34
▸ SLC18A3 Q16572 1/20 0.34
▸ SLC6A4 P31645 1/20 0.33
▸ ABL1 P00519 1/20 0.33
▸ PRKAB2 O43741 1/20 0.33
▸ PRKAG1 P54619 1/20 0.33
▸ PRKAA2 P54646 1/20 0.33
▸ PRKAA1 Q13131 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2479088 0.91 KDM4E (0.39) KDM4EABCB1ABCG2SLC18A3
SCHEMBL2479695 0.89 PDE10A (0.34) SMPD3MCHR1KDM4ESLC18A3
SCHEMBL2477886 0.78 ALDH1A1 (0.47) —
SCHEMBL15382192 0.77 SMPD3 (0.47) SMPD3MCHR1SUV39H2KDM4ERAD52
SCHEMBL14940517 0.76 ALDH1A1 (0.46) —
SCHEMBL1930421 0.75 NR4A1 (0.48) SMPD3MCHR1SUV39H2KDM4ERAD52
SCHEMBL15650970 0.75 NR4A1 (0.48) SMPD3MCHR1SUV39H2KDM4ERAD52
SCHEMBL1930423 0.75 NR4A1 (0.48) SMPD3MCHR1SUV39H2KDM4ERAD52
SCHEMBL188354 0.75 DRD2 (0.60) KDM4E
SCHEMBL12257804 0.74 ACACB (0.47) SMPD3MCHR1SUV39H2RAD52

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2373169-B1 IMIDAZOPYRAZINE SYK INHIBITORS GILEAD CONNECTICUT INC (US) 2015-05-20 — — EP claimed
US-20140336169-A1 IMIDAZOPYRAZINE SYK INHIBITORS GILEAD CONNECTICUT, INC. (US) 2014-11-13 — — US claimed
US-8748607-B2 Imidazopyrizine syk inhibitors GILEAD CONNECTICUT, INC. (US) 2014-06-10 — — US claimed
US-20130237521-A1 IMIDAZOPYRIZINE SYK INHIBITORS GILEAD CONNECTICUT, INC. (US) 2013-09-12 — — US claimed
US-20130237520-A1 IMIDAZOPYRAZINE SYK INHIBITORS GILEAD CONNECTICUT, INC. (US) 2013-09-12 — — US claimed
US-8455493-B2 Imidazopyrazine Syk inhibitors GILEAD CONNECTICUT, INC. (US) 2013-06-04 — — US claimed
EP-2373169-A1 IMIDAZOPYRAZINE SYK INHIBITORS Gilead Connecticut, Inc. (US) 2011-10-12 — — EP claimed
US-20100222323-A1 IMIDAZOPYRAZINE SYK INHIBITORS Kronos Bio, Inc. 2010-09-02 — — US claimed
WO-2010068257-A1 IMIDAZOPYRAZINE SYK INHIBITORS CGI PHARMACEUTICALS, INC. (US) 2010-06-17 — — WO claimed
US-20180086769-A1 IMIDAZOPYRAZINE SYK INHIBITORS Kronos Bio, Inc. 2018-03-29 — — US disclosed
US-9796718-B2 6-(benzo[d]thiazol-5-yl)-n-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyrazin-8-amine GILEAD CONNECTICUT, INC. (US) 2017-10-24 — — US disclosed
EP-3123864-A1 IMIDAZOPYRAZINE SYK INHIBITORS Gilead Connecticut, Inc. (US) 2017-02-01 — — EP disclosed
EP-2716157-B1 Imidazopyrazine Syk inhibitors GILEAD CONNECTICUT INC (US) 2016-05-18 — — EP disclosed
US-20160031894-A1 IMIDAZOPYRAZINE SYK INHIBITORS Kronos Bio, Inc. 2016-02-04 — — US disclosed
US-8455493-B2 Imidazopyrazine Syk inhibitors GILEAD CONNECTICUT, INC. (US) 2013-06-04 — — US disclosed
US-8450321-B2 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor GILEAD CONNECTICUT, INC. (US) 2013-05-28 — — US disclosed
US-20120220582-A1 IMIDAZOPYRAZINE SYK INHIBITORS GILEAD CONNECTICUT, INC. (US) 2012-08-30 — — US disclosed
EP-2373169-A1 IMIDAZOPYRAZINE SYK INHIBITORS Gilead Connecticut, Inc. (US) 2011-10-12 — — EP disclosed
US-20100222323-A1 IMIDAZOPYRAZINE SYK INHIBITORS Kronos Bio, Inc. 2010-09-02 — — US disclosed
WO-2010068257-A1 IMIDAZOPYRAZINE SYK INHIBITORS CGI PHARMACEUTICALS, INC. (US) 2010-06-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160031894-A1 IMIDAZOPYRAZINE SYK INHIBITORS SYK, BTK, ZAP70 SMPD3 1257/4885MCHR1 4116/4885SUV39H2 2339/4885
US-20120220582-A1 IMIDAZOPYRAZINE SYK INHIBITORS SYK, BTK, ZAP70 SMPD3 1257/4885MCHR1 4116/4885SUV39H2 2339/4885
US-20130237520-A1 IMIDAZOPYRAZINE SYK INHIBITORS SYK, BTK, ZAP70 SMPD3 1257/4885MCHR1 4116/4885SUV39H2 2339/4885
US-20180086769-A1 IMIDAZOPYRAZINE SYK INHIBITORS SYK, BTK, ZAP70 SMPD3 1257/4885MCHR1 4116/4885SUV39H2 2339/4885
US-20140336169-A1 IMIDAZOPYRAZINE SYK INHIBITORS SYK, BTK, ZAP70 SMPD3 1257/4885MCHR1 4116/4885SUV39H2 2339/4885
US-20100222323-A1 IMIDAZOPYRAZINE SYK INHIBITORS SYK, BTK, ZAP70 SMPD3 1257/4885MCHR1 4116/4885SUV39H2 2339/4885
US-20130237521-A1 IMIDAZOPYRIZINE SYK INHIBITORS SYK, ZAP70, BTK SMPD3 1552/4885MCHR1 4393/4885SUV39H2 2469/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.