SCHEMBL14940517

SCHEMBL14940517

COc1c[c]ccc1N1CCCCC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.46
ALDH1A3 P47895 1/20 0.46
SMN1; SMN2 Q16637 3/20 0.41
USP2 O75604 1/20 0.41
DRD2 P14416 4/20 0.41
DRD3 P35462 3/20 0.41
MAPT P10636 2/20 0.41
HTR3E A5X5Y0 2/20 0.40
HTR3B O95264 2/20 0.40
HTR3A P46098 2/20 0.40
HTR3D Q70Z44 2/20 0.40
HTR3C Q8WXA8 2/20 0.40
ADRB1 P08588 1/20 0.40
CYP2C19 P33261 1/20 0.40
HTR6 P50406 1/20 0.40
SIGMAR1 Q99720 1/20 0.40
LMNA P02545 1/20 0.39
TP53 P04637 1/20 0.39
HPGD P15428 1/20 0.39
TSHR P16473 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2477886 0.98 ALDH1A1 (0.47) ALDH1A1ALDH1A3SMN1; SMN2USP2DRD2
SCHEMBL188354 0.85 DRD2 (0.60) ALDH1A1SMN1; SMN2USP2DRD2DRD3
SCHEMBL2479623 0.84 ALDH1A1 (0.44) ALDH1A1ALDH1A3SMN1; SMN2USP2DRD2
SCHEMBL2481232 0.83 AKR1C3 (0.46) ALDH1A1SMN1; SMN2DRD2DRD3MAPT
SCHEMBL2479088 0.82 KDM4E (0.39) ALDH1A1SMN1; SMN2USP2DRD2DRD3
SCHEMBL2481239 0.81 DRD2 (0.49) ALDH1A1SMN1; SMN2DRD2DRD3MAPT
SCHEMBL2479695 0.77 PDE10A (0.34) ALDH1A1SMN1; SMN2DRD2DRD3MAPT
SCHEMBL14940417 0.77 ALDH1A3 (0.45) ALDH1A1ALDH1A3SMN1; SMN2MAPTADRB1
SCHEMBL2477801 0.76 SMPD3 (0.42)
SCHEMBL283083 0.76 DRD2 (0.47) ALDH1A1DRD2DRD3HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013068592-A1 INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE FONDATION JEROME LEJEUNE (FR) 2013-05-16 WO disclosed