Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP7 | Q93009 | 3/20 | 0.36 |
| ▸ | APP | P05067 | 2/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | NMT1 | P30419 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | QDPR | P09417 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31142581 | 0.89 | CHEK2 (0.42) | SLC6A2SLC6A4CHEK2SLC6A3NOS3 | |
| SCHEMBL3720637 | 0.86 | APP (0.42) | APPESR1ESR2DRD2DRD4 | |
| SCHEMBL4577662 | 0.83 | SLC6A4 (0.46) | NMT1SLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL26011715 | 0.81 | NMT1 (0.35) | NMT1SLC6A2SLC6A4SLC6A3IRAK4 | |
| SCHEMBL1866454 | 0.81 | ALDH1A1 (0.43) | NMT1SLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL16422572 | 0.81 | SLC6A4 (0.48) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2092295 | 0.81 | NOS2 (0.44) | SLC6A2SLC6A4SLC6A3NOS3NOS1 | |
| SCHEMBL6872363 | 0.81 | TYR (0.44) | APPESR1MEN1KMT2A | |
| SCHEMBL4010135 | 0.81 | SLC18A3 (0.45) | SLC6A2SLC6A4SLC6A3MEN1LMNA | |
| Hydrochloric Acid SCHEMBL25356942 | 0.80 | NMT1 (0.34) | NMT1SLC6A2SLC6A4SLC6A3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373163-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010080503-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-07-15 | — | — | WO | disclosed |