Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | TYR | P14679 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6872363 | 0.90 | TYR (0.44) | APPTYRKDM4EMEN1ALDH1A1 | |
| SCHEMBL2477882 | 0.86 | USP7 (0.36) | APPESR2DRD2DRD4DRD3 | |
| SCHEMBL31142581 | 0.79 | CHEK2 (0.42) | — | |
| SCHEMBL10398543 | 0.78 | DRD3 (0.42) | APPDRD2DRD4DRD3MEN1 | |
| SCHEMBL3717754 | 0.77 | CYP2A6 (0.36) | MEN1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL22314754 | 0.77 | ALDH1A1 (0.52) | KDM4EMEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL5480634 | 0.77 | DDB1 (0.50) | APPTRPA1ACHE | |
| SCHEMBL2616319 | 0.77 | FPR2 (0.46) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL5791711 | 0.77 | APP (0.42) | APPDRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL4485887 | 0.76 | HRH4 (0.44) | KDM4EMEN1ALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | disclosed |