Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | TACR2 | P21452 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3411402 | 0.93 | TSHR (0.49) | TSHRHPGDMAPTHTR2CHTR2B | |
| SCHEMBL2525158 | 0.86 | TSHR (0.56) | TSHRHPGDMAPTHTR2CHTR2B | |
| SCHEMBL21596050 | 0.81 | MAPT (0.59) | TSHRHPGDMAPTSLC6A2SLC6A4 | |
| SCHEMBL2477340 | 0.79 | MAPT (0.53) | TSHRHPGDMAPTGAAATM | |
| SCHEMBL4284080 | 0.79 | SLC6A4 (0.48) | TSHRHTR2ASLC6A2SLC6A4TDP1 | |
| SCHEMBL519223 | 0.79 | TRPV4 (0.47) | TSHRHPGDMAPTSLC6A2SLC6A4 | |
| SCHEMBL4018504 | 0.78 | L3MBTL1 (0.46) | TSHRHPGDMAPTCYP1A2CYP2D6 | |
| SCHEMBL23251387 | 0.77 | TSHR (0.47) | TSHRHPGDMAPTHTR2CHTR2B | |
| SCHEMBL12468187 | 0.77 | CYP1A2 (0.55) | TSHRHPGDMAPTHTR2CHTR2B | |
| SCHEMBL1547765 | 0.76 | TDP1 (0.56) | TSHRHPGDMAPTATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265583-B1 | SPIROINDOLINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-10-12 | — | — | EP | disclosed |
| EP-2265583-A1 | SPIROINDOLINONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-12-29 | — | — | EP | disclosed |
| US-7723372-B2 | Spiroindolinone derivatives | HOFFMAN-LA ROCHE INC. (US) | 2010-05-25 | — | — | US | disclosed |
| WO-2009115425-A1 | SPIROINDOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-24 | — | — | WO | disclosed |
| US-20090239889-A1 | Spiroindolinone Derivatives | LIU JIN-JUN | 2009-09-24 | — | — | US | disclosed |
| US-20090099183-A1 | PYRIMIDINES AND USES THEREOF | CELL THERAPEUTICS, INC. (US) | 2009-04-16 | — | — | US | disclosed |
| US-7419984-B2 | Pyrimidines and uses thereof | CELL THERAPEUTICS, INC. (US) | 2008-09-02 | — | — | US | disclosed |
| US-20040204386-A1 | Pyrimidines and uses thereof | CELL THERAPEUTICS, INC. | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204386-A1 | Pyrimidines and uses thereof | LPCAT3, LPCAT1, APRT | TSHR 4049/4885HPGD 1097/4885MAPT 3800/4885 |
| US-20090099183-A1 | PYRIMIDINES AND USES THEREOF | LPCAT3, LPCAT1, APRT | TSHR 4067/4885HPGD 1452/4885MAPT 3707/4885 |
| US-20090239889-A1 | Spiroindolinone Derivatives | CCNY, RB1, NQO1 | TSHR 1208/4885HPGD 817/4885MAPT 4069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.