Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 17/20 | 0.68 |
| ▸ | HTT | P42858 | 16/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.68 |
| ▸ | NPC1 | O15118 | 9/20 | 0.68 |
| ▸ | MITF | O75030 | 8/20 | 0.68 |
| ▸ | MAPT | P10636 | 10/20 | 0.53 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.53 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 9/20 | 0.52 |
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 12/20 | 0.50 |
| ▸ | LMNA | P02545 | 10/20 | 0.50 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9827518 | 0.86 | ALDH1A1 (0.57) | ALDH1A1HTTSMN1; SMN2NPC1MITF | |
| SCHEMBL24779602 | 0.84 | ALDH1A1 (0.64) | ALDH1A1HTTSMN1; SMN2NPC1MITF | |
| SCHEMBL2895158 | 0.81 | ALDH1A1 (0.61) | ALDH1A1HTTSMN1; SMN2NPC1MITF | |
| SCHEMBL2888078 | 0.78 | HTT (0.69) | ALDH1A1HTTSMN1; SMN2NPC1MITF | |
| SCHEMBL11142528 | 0.75 | HTT (0.65) | ALDH1A1HTTSMN1; SMN2NPC1MITF | |
| SCHEMBL24779776 | 0.75 | HTT (0.65) | ALDH1A1HTTSMN1; SMN2NPC1MITF | |
| SCHEMBL31735924 | 0.75 | HTT (0.64) | ALDH1A1HTTSMN1; SMN2NPC1MITF | |
| SCHEMBL29452248 | 0.75 | ALDH1A1 (0.64) | ALDH1A1HTTSMN1; SMN2NPC1MITF | |
| SCHEMBL9239777 | 0.74 | ALDH1A1 (0.63) | ALDH1A1HTTSMN1; SMN2NPC1MITF | |
| SCHEMBL9373009 | 0.74 | HTT (0.63) | ALDH1A1HTTSMN1; SMN2NPC1MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022258992-A1 | PYRIDAZINONES FOR THE TREATMENT OR PREVENTION OF HYPERTENSION | UNIVERSITETET I OSLO (NO) | 2022-12-15 | — | — | WO | disclosed |