Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 14/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.69 |
| ▸ | MITF | O75030 | 10/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.69 |
| ▸ | NPC1 | O15118 | 8/20 | 0.69 |
| ▸ | MAPT | P10636 | 9/20 | 0.65 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.65 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 13/20 | 0.60 |
| ▸ | LMNA | P02545 | 8/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 8/20 | 0.58 |
| ▸ | POLB | P06746 | 5/20 | 0.58 |
| ▸ | RECQL | P46063 | 4/20 | 0.56 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11142528 | 0.86 | HTT (0.65) | HTTALDH1A1MITFSMN1; SMN2NPC1 | |
| SCHEMBL24779776 | 0.86 | HTT (0.65) | HTTALDH1A1MITFSMN1; SMN2NPC1 | |
| SCHEMBL10876189 | 0.84 | HTT (0.55) | HTTALDH1A1MITFSMN1; SMN2NPC1 | |
| SCHEMBL29451310 | 0.82 | ALDH1A1 (0.53) | HTTALDH1A1MITFSMN1; SMN2NPC1 | |
| SCHEMBL29451678 | 0.82 | HTT (0.49) | HTTALDH1A1MITFSMN1; SMN2NPC1 | |
| SCHEMBL29452248 | 0.82 | ALDH1A1 (0.64) | HTTALDH1A1MITFSMN1; SMN2NPC1 | |
| SCHEMBL24779602 | 0.82 | ALDH1A1 (0.64) | HTTALDH1A1MITFSMN1; SMN2NPC1 | |
| SCHEMBL31735924 | 0.82 | HTT (0.64) | HTTALDH1A1MITFSMN1; SMN2NPC1 | |
| SCHEMBL15674046 | 0.81 | HTT (0.58) | HTTALDH1A1MITFSMN1; SMN2NPC1 | |
| SCHEMBL29451307 | 0.81 | ALDH1A1 (0.48) | HTTALDH1A1MITFSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240300904-A1 | PYRIDAZINONES FOR THE TREATMENT OR PREVENTION OF HYPERTENSION | UNIVERSITETET I OSLO (NO) | 2024-09-12 | — | — | US | disclosed |
| EP-4351518-A1 | PYRIDAZINONES FOR THE TREATMENT OR PREVENTION OF HYPERTENSION | Universitetet I Oslo (NO) | 2024-04-17 | — | — | EP | disclosed |
| WO-2022258992-A1 | PYRIDAZINONES FOR THE TREATMENT OR PREVENTION OF HYPERTENSION | UNIVERSITETET I OSLO (NO) | 2022-12-15 | — | — | WO | disclosed |
| WO-2022258992-A1 | PYRIDAZINONES FOR THE TREATMENT OR PREVENTION OF HYPERTENSION | UNIVERSITETET I OSLO (NO) | 2022-12-15 | — | — | WO | disclosed |
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |
| US-8440666-B2 | Pyridazinone compounds and P2X7 receptor inhibitors | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2013-05-14 | — | — | US | disclosed |
| US-20100286390-A1 | PYRIDAZINONE COMPOUNDS AND P2X7 RECEPTOR INHIBITORS | NISSAN CHEMICAL INDUSTRIES LIMITED | 2010-11-11 | — | — | US | disclosed |
| EP-0201765-B1 | 3(2H)PYRIDAZINONE, PROCESS FOR ITS PREPARATION AND ANTI-ALLERGIC AGENT CONTAINING IT | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1991-09-18 | — | — | EP | disclosed |
| US-4892947-A | 3(2H)Pyridazinone, process for its preparation and anti-allergic agent containing it | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1990-01-09 | — | — | US | disclosed |
| EP-0201765-A2 | 3(2H)Pyridazinone, process for its preparation and anti-allergic agent containing it | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1986-11-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240300904-A1 | PYRIDAZINONES FOR THE TREATMENT OR PREVENTION OF HYPERTENSION | REN, AGTR1, AGTR2 | HTT 1857/4885ALDH1A1 623/4885MITF 3519/4885 |
| US-20100286390-A1 | PYRIDAZINONE COMPOUNDS AND P2X7 RECEPTOR INHIBITORS | P2RY1, P2RX7, P2RX1 | HTT 4503/4885ALDH1A1 2584/4885MITF 2814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.