Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 3/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25744603 | 0.85 | RIPK1 (0.42) | RIPK1DDR1ALDH1A1APOBEC3G | |
| SCHEMBL16844673 | 0.80 | PTGS2 (0.51) | PTGS2HTR7CHRM4DDR1PDE5A | |
| SCHEMBL10350653 | 0.77 | PTGS2 (0.55) | PTGS2HTR7PDE5ASOAT1ALDH1A1 | |
| SCHEMBL30548746 | 0.77 | PTGS2 (0.55) | PTGS2HTR7PDE5ASOAT1ALDH1A1 | |
| SCHEMBL9210463 | 0.77 | PTGS2 (0.45) | PTGS2HTR7CHRM4DDR1PDE5A | |
| SCHEMBL26942237 | 0.77 | APOBEC3G (0.57) | PTGS2HTR7CHRM4DDR1PDE5A | |
| SCHEMBL13402025 | 0.76 | CHRM2 (0.46) | RIPK1HTR7CHRM4ALDH1A1APOBEC3G | |
| SCHEMBL6685097 | 0.72 | RIPK1 (0.56) | RIPK1 | |
| SCHEMBL3628525 | 0.70 | MEN1 (0.54) | PTGS2PDE5ASOAT1ALDH1A1APOBEC3G | |
| SCHEMBL10144088 | 0.70 | PTGS2 (0.49) | PTGS2HTR7PDE5ASOAT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3849968-B1 | 1H-INDAZOLE CARBOXAMIDES AS RECEPTOR-INTERACTING PROTEIN KINASE 1 INHIBITORS (RIPK1) | BRISTOL MYERS SQUIBB CO (US) | 2022-12-21 | — | — | EP | disclosed |