SCHEMBL247830

SCHEMBL247830

Cc1cc(C)c(C2CC2)cc1CC(=O)O

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.39
ALOX15 P16050 2/20 0.38
RXRA P19793 2/20 0.38
RXRB P28702 2/20 0.38
RXRG P48443 1/20 0.37
PTGS2 P35354 3/20 0.36
HPGD P15428 1/20 0.36
TSHR P16473 1/20 0.36
SRC P12931 1/20 0.36
PTGDR2 Q9Y5Y4 1/20 0.35
PTGS1 P23219 1/20 0.34
NR1H4 Q96RI1 1/20 0.34
MAPT P10636 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
MEN1 O00255 1/20 0.33
POLB P06746 1/20 0.33
KMT2A Q03164 1/20 0.33
GPR35 Q9HC97 1/20 0.33
FFAR4 Q5NUL3 1/20 0.33
OPRL1 P41146 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ether SCHEMBL27817334 0.91 PTGDR2 (0.34) NPSR1ALOX15RXRARXRBRXRG
SCHEMBL249012 0.85 SLC6A3 (0.37) NPSR1OPRL1
SCHEMBL245882 0.82 PDGFRB (0.39) HPGDPTGDR2MAPTSMN1; SMN2MEN1
SCHEMBL5490049 0.77 NPSR1 (0.56) NPSR1ALOX15RXRARXRBRXRG
SCHEMBL31674346 0.77 NPSR1 (0.56) NPSR1ALOX15RXRARXRBRXRG
SCHEMBL11325941 0.77 NPSR1 (0.60) NPSR1ALOX15RXRARXRBRXRG
SCHEMBL10299408 0.76 PTGDR2 (0.43) NPSR1ALOX15PTGS2PTGDR2
SCHEMBL11393898 0.76 PTGDR2 (0.43) PTGDR2MEN1POLBKMT2A
SCHEMBL27817381 0.76 HSD17B10 (0.38) PTGS2SMN1; SMN2MEN1KMT2AFFAR4
SCHEMBL20844642 0.75 RXRA (0.47) NPSR1ALOX15RXRARXRBRXRG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2352375-B1 HERBICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2015-03-25 EP disclosed
EP-2352375-B1 HERBICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2015-03-25 EP disclosed
US-8722578-B2 Spiroheterocyclic pyrrolidinedione herbicidal compositions SYNGENTA PARTICIPATIONS AG (CH) 2014-05-13 US disclosed
US-8722578-B2 Spiroheterocyclic pyrrolidinedione herbicidal compositions SYNGENTA PARTICIPATIONS AG (CH) 2014-05-13 US disclosed
US-8722578-B2 Spiroheterocyclic pyrrolidinedione herbicidal compositions SYNGENTA PARTICIPATIONS AG (CH) 2014-05-13 US disclosed
EP-2421865-B1 SPIROHETEROCYCLIC PYRROLIDINE DIONE DERIVATIVES USED AS PESTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2013-07-10 EP disclosed
EP-2421865-B1 SPIROHETEROCYCLIC PYRROLIDINE DIONE DERIVATIVES USED AS PESTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2013-07-10 EP disclosed
US-8415369-B2 Spiroheterocyclic pyrrolidine dione derivatives useful as pesticides SYNGENTA CROP PROTECTION LLC (US) 2013-04-09 US disclosed
US-8415369-B2 Spiroheterocyclic pyrrolidine dione derivatives useful as pesticides SYNGENTA CROP PROTECTION LLC (US) 2013-04-09 US disclosed
EP-2197844-B1 SPIROHETEROCYCLIC PYRROLIDINE DIONE DERIVATIVES USEFUL AS PESTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2012-07-25 EP disclosed
US-20100311777-A1 SPIROHETEROCYCLIC PYRROLIDINE DIONE DERIVATIVES USEFUL AS PESTICIDES SYNGENTA CROP PROTECTION, INC. (US) 2010-12-09 US disclosed
US-20100311777-A1 SPIROHETEROCYCLIC PYRROLIDINE DIONE DERIVATIVES USEFUL AS PESTICIDES SYNGENTA CROP PROTECTION, INC. (US) 2010-12-09 US disclosed
US-20100311777-A1 SPIROHETEROCYCLIC PYRROLIDINE DIONE DERIVATIVES USEFUL AS PESTICIDES SYNGENTA CROP PROTECTION, INC. (US) 2010-12-09 US disclosed
WO-2010115780-A1 SPIROHETEROCYCLIC PYRROLIDINE DIONE DERIVATIVES USED AS PESTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2010-10-14 WO disclosed
WO-2010115780-A1 SPIROHETEROCYCLIC PYRROLIDINE DIONE DERIVATIVES USED AS PESTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2010-10-14 WO disclosed
CN-101827815-A Spiroheterocyclic pyrrolidine dione derivatives as pesticides SYNGENTA PARTICIPATIONS AGSYNGENTA PARTICIPATIONS AG 2010-09-08 CN disclosed
EP-2197844-A1 SPIROHETEROCYCLIC PYRROLIDINE DIONE DERIVATIVES USEFUL AS PESTICIDES Syngeta Participations AG (CH) 2010-06-23 EP disclosed
WO-2010052161-A2 HERBICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2010-05-14 WO disclosed
WO-2010052161-A2 HERBICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2010-05-14 WO disclosed
WO-2009049851-A1 SPIROHETEROCYCLIC PYRROLIDINE DIONE DERIVATIVES USEFUL AS PESTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2009-04-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100311777-A1 SPIROHETEROCYCLIC PYRROLIDINE DIONE DERIVATIVES USEFUL AS PESTICIDES DDT, PKD2, PKD1 NPSR1 325/4885ALOX15 3905/4885RXRA 729/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.