Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.39 |
| ▸ | GRK6 | P43250 | 1/20 | 0.38 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.36 |
| ▸ | CYP2A7 | P20853 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30103072 | 0.85 | KDM1A (0.40) | KDM1ACYP4F2CYP4A11GRK6ALKBH1 | |
| SCHEMBL24784603 | 0.85 | KDM1A (0.40) | KDM1ACYP4F2CYP4A11GRK6ALKBH1 | |
| SCHEMBL30516644 | 0.81 | KDM1A (0.55) | KDM1ACYP11B1CYP11B2CYP1A1CYP1B1 | |
| SCHEMBL25367014 | 0.81 | KDM1A (0.55) | KDM1ACYP11B1CYP11B2CYP1A1CYP1B1 | |
| SCHEMBL30018769 | 0.78 | GRM5 (0.44) | KDM1ACYP4F2CYP4A11CYP1A1CYP1B1 | |
| SCHEMBL24784637 | 0.78 | GRM5 (0.44) | KDM1ACYP4F2CYP4A11CYP1A1CYP1B1 | |
| SCHEMBL30103004 | 0.77 | KDM1A (0.41) | KDM1ACYP4F2CYP4A11GRK6ALKBH1 | |
| SCHEMBL24785334 | 0.77 | KDM1A (0.41) | KDM1ACYP4F2CYP4A11GRK6ALKBH1 | |
| SCHEMBL24785094 | 0.77 | CLK4 (0.63) | CYP1A2CYP3A4CYP2D6CYP2C19DYRK1A | |
| SCHEMBL26784179 | 0.76 | ABL1 (0.49) | CYP4F2CYP4A11PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022257960-A1 | BICYCLIC COMPOUND FOR THE TREATMENT OF EP2 AND EP4 RECEPTOR-MEDIATED DISEASES | 武汉人福创新药物研发中心有限公司 | 2022-12-15 | — | — | WO | disclosed |
| WO-2022257960-A1 | BICYCLIC COMPOUND FOR THE TREATMENT OF EP2 AND EP4 RECEPTOR-MEDIATED DISEASES | 武汉人福创新药物研发中心有限公司 | 2022-12-15 | — | — | WO | disclosed |
| CN-115448913-A | Bicyclic compounds for the treatment of EP2, EP4 receptor mediated diseases | 武汉人福创新药物研发中心有限公司 | 2022-12-09 | — | — | CN | disclosed |