Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22307606 | 0.79 | GBA1 (0.33) | GBA1 | |
| SCHEMBL16939206 | 0.75 | — | — | |
| SCHEMBL16356174 | 0.72 | — | — | |
| SCHEMBL10159852 | 0.69 | KDM4E (0.34) | — | |
| SCHEMBL17826725 | 0.69 | SLC6A3 (0.38) | GBA1CA1CA2CA4 | |
| SCHEMBL18723476 | 0.69 | SLC6A3 (0.38) | GBA1CA1CA2CA4 | |
| SCHEMBL18488841 | 0.68 | GBA1 (0.40) | GBA1 | |
| SCHEMBL24179782 | 0.67 | KDM4E (0.30) | — | |
| SCHEMBL12616743 | 0.67 | GBA1 (0.48) | GBA1 | |
| SCHEMBL19251572 | 0.67 | NOS1 (0.31) | CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022261427-A1 | (4-(6-((2-OCTAHYDROCYCLOPENTA[C]PYRROL-5-YL)AMINO)PYRIDAZIN-3-YL)PHENYL)(IMINO)(METHYL)-LAMBDA6- SULFANONE DERIVATIVES AND SIMILAR COMPOUNDS AS MUSCARINIC ACETYLCHOLINE RECEPTOR M4 ANTAGONISTS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | VANDERBILT UNIVERSITY (US) | 2022-12-15 | — | — | WO | disclosed |