Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | MGLL | Q99685 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 3/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CCR2 | P41597 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2476185 | 0.88 | CA12 (0.55) | NPC1LMNACYP2C19CYP1A2SMN1; SMN2 | |
| SCHEMBL2480782 | 0.88 | NPC1 (0.56) | NPC1ALDH1A1LMNACYP2C19SMN1; SMN2 | |
| SCHEMBL2473719 | 0.87 | NPC1 (0.66) | NPC1MGLLALDH1A1CYP2D6LMNA | |
| SCHEMBL2474761 | 0.81 | RAB9A (0.60) | NPC1LMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL2476567 | 0.81 | TSHR (0.56) | NPC1LMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL2476936 | 0.81 | NPC1 (0.64) | NPC1ALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL2477929 | 0.81 | SMN1; SMN2 (0.50) | NPC1ALDH1A1CYP2C19SMN1; SMN2MEN1 | |
| SCHEMBL13841263 | 0.79 | LMNA (0.81) | NPC1ALDH1A1CYP2D6LMNAUSP2 | |
| SCHEMBL10368891 | 0.76 | NPC1 (0.64) | NPC1ALDH1A1CYP2D6LMNAUSP2 | |
| SCHEMBL2475564 | 0.76 | FNTA (0.46) | NPC1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373620-A1 | NOVEL 4-(AZACYCLOALKYL)BENZENE-1,3-DIOL COMPOUNDS AS TYROSINASE INHIBITORS, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS | Galderma Research & Development (FR) | 2011-10-12 | — | — | EP | disclosed |