Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2474761 | 0.93 | RAB9A (0.60) | CA12CA1CA2CA9KMT2A | |
| SCHEMBL2478741 | 0.88 | NPC1 (0.67) | KMT2ANPC1MAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL2476567 | 0.88 | TSHR (0.56) | CA12CA1CA2CA9KMT2A | |
| SCHEMBL2480782 | 0.88 | NPC1 (0.56) | CA12CA1CA2CA9NPC1 | |
| SCHEMBL16564209 | 0.82 | MMP1 (0.41) | CA12CA1CA2CA9NPC1 | |
| SCHEMBL2474909 | 0.82 | ALDH1A1 (0.56) | KMT2ANPC1SMN1; SMN2MEN1TSHR | |
| SCHEMBL2500299 | 0.81 | ROCK2 (0.49) | — | |
| SCHEMBL2476685 | 0.81 | TRPV1 (0.56) | NPC1MAPTRAB9ASMN1; SMN2TRPV1 | |
| SCHEMBL2476936 | 0.81 | NPC1 (0.64) | NPC1MAPTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL16564264 | 0.78 | NPC1 (0.39) | CA12CA1CA2CA9NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373620-A1 | NOVEL 4-(AZACYCLOALKYL)BENZENE-1,3-DIOL COMPOUNDS AS TYROSINASE INHIBITORS, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS | Galderma Research & Development (FR) | 2011-10-12 | — | — | EP | disclosed |