Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 3/20 | 0.34 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25399504 | 0.85 | TMPRSS2 (0.44) | TMPRSS2ABL1RIN1TDP1ALDH1A1 | |
| SCHEMBL16708473 | 0.82 | TMPRSS2 (0.49) | TMPRSS2TDP1ADORA3 | |
| SCHEMBL25401476 | 0.80 | TMPRSS2 (0.38) | TMPRSS2ABL1RIN1TDP1ALDH1A1 | |
| SCHEMBL16708477 | 0.80 | TMPRSS2 (0.47) | TMPRSS2TDP1POLBADORA3 | |
| SCHEMBL16708472 | 0.78 | TMPRSS2 (0.42) | TMPRSS2TDP1ALDH1A1NPC1ATM | |
| SCHEMBL16708480 | 0.77 | TMPRSS2 (0.43) | TMPRSS2ABL1RIN1TDP1ALDH1A1 | |
| SCHEMBL14642742 | 0.77 | POLRMT (0.39) | ADORA3DOT1L | |
| SCHEMBL21120506 | 0.77 | POLRMT (0.39) | ADORA3DOT1L | |
| SCHEMBL10154352 | 0.77 | POLRMT (0.39) | ADORA3DOT1L | |
| SCHEMBL19101806 | 0.77 | TMPRSS2 (0.42) | TMPRSS2ABL1RIN1TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022265964-A1 | ORALLY-BIOAVAILABLE NUCLEOSIDE ANALOGS | VenatoRx Pharmaceuticals, Inc. (US) | 2022-12-22 | — | — | WO | disclosed |