Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 4/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27174522 | 0.82 | MKNK1 (0.47) | TRPV1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL27174339 | 0.82 | TRPV1 (0.41) | ADRB2TRPV1GABRA1GABRG2GABRB3 | |
| SCHEMBL31521744 | 0.82 | MKNK1 (0.47) | TRPV1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL31306178 | 0.79 | TRPV1 (0.43) | TAAR1TRPV1GABRA1GABRG2GABRB3 | |
| SCHEMBL30007391 | 0.79 | MAPK14 (0.53) | TRPV1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL30211300 | 0.79 | MAPK14 (0.53) | TRPV1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL24792396 | 0.79 | ADRB2 (0.56) | ADRB2CYP2A6HRH3TAAR1LOXL2 | |
| SCHEMBL28242972 | 0.78 | ADRB2 (0.59) | ADRB2CYP2A6HRH3TAAR1LOXL2 | |
| SCHEMBL24791498 | 0.78 | ADRB2 (0.51) | ADRB2CYP2A6HRH3TAAR1MAOB | |
| SCHEMBL2639667 | 0.77 | FEN1 (0.43) | CYP2A6TRPV1GABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117940427-A | Substituted pyrazolo [1,5-a ] pyrimidine-7-amine compounds as CDK inhibitors and therapeutic uses thereof | 卡里克治疗有限公司 | 2024-04-26 | — | — | CN | disclosed |
| EP-4355426-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE | Carrick Therapeutics Limited (IE) | 2024-04-24 | — | — | EP | disclosed |
| WO-2022263604-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE | Carrick Therapeutics Limited (IE) | 2022-12-22 | — | — | WO | disclosed |
| WO-2022263604-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE | Carrick Therapeutics Limited (IE) | 2022-12-22 | — | — | WO | disclosed |