Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethyl Sulfoxide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1956001 | 0.95 | HTR6 (0.38) | CYP2C9CYP2C19CYP1A2SMN1; SMN2HTR6 | |
| Dimethyl Sulfoxide SCHEMBL2405986 | 0.81 | ALDH1A1 (0.44) | CYP2C9CYP2C19CYP1A2SMN1; SMN2KMT2A | |
| SCHEMBL1955955 | 0.81 | HTR6 (0.35) | CYP2C9CYP2C19CYP1A2SMN1; SMN2HTR6 | |
| SCHEMBL1957162 | 0.78 | CYP2C9 (0.47) | CYP2C9CYP2C19CYP1A2SMN1; SMN2HTR6 | |
| SCHEMBL2386869 | 0.76 | ALDH1A1 (0.49) | CYP2C9CYP2C19CYP1A2SMN1; SMN2KMT2A | |
| SCHEMBL27910608 | 0.74 | MAPT (0.51) | CYP2C9CYP2C19CYP1A2SMN1; SMN2HTR6 | |
| SCHEMBL1955377 | 0.74 | LTA4H (0.53) | CYP2C9CYP2C19HTR6KMT2AHSD17B10 | |
| SCHEMBL1959118 | 0.71 | ALDH1A1 (0.49) | SMN1; SMN2HTR6KMT2AMEN1ALDH1A1 | |
| SCHEMBL27850273 | 0.71 | HTR6 (0.42) | CYP2C9CYP2C19CYP1A2SMN1; SMN2HTR6 | |
| SCHEMBL1955303 | 0.71 | PDK2 (0.51) | CYP2C9CYP2C19SMN1; SMN2KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376480-A2 | SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES | Abbott Laboratories (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010065865-A2 | BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2010-06-10 | — | — | WO | disclosed |