⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2628907 | 0.75 | SIGMAR1 (0.50) | — | |
| SCHEMBL6961571 | 0.64 | — | — | |
| SCHEMBL4216433 | 0.64 | — | — | |
| SCHEMBL1804278 | 0.64 | — | — | |
| SCHEMBL1101400 | 0.64 | — | — | |
| Hydrochloric Acid SCHEMBL29471655 | 0.62 | — | — | |
| SCHEMBL30679852 | 0.61 | — | — | |
| SCHEMBL9572488 | 0.60 | — | — | |
| SCHEMBL861254 | 0.60 | — | — | |
| SCHEMBL3949066 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-11100370-A | — | — | None | — | — | JP | disclosed |
| EP-4126844-A1 | AMIDE COMPOUNDS AND USES THEREOF | Hutchison Medipharma Limited (CN) | 2023-02-08 | — | — | EP | disclosed |
| WO-2021197276-A1 | Amide compounds and uses thereof | HUTCHISON MEDIPHARMA LIMITED (CN) | 2021-10-07 | — | — | WO | disclosed |
| EP-2373636-A1 | INHIBITORS OF PHOSPHOINOSITIDE DEPENDENT KINASE 1 (PDK1) | Merck Sharp & Dohme Corp. (US) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010065384-A1 | INHIBITORS OF PHOSPHOINOSITIDE DEPENDENT KINASE 1 (PDK1) | MERCK SHARP & DOHME CORP. (US) | 2010-06-10 | — | — | WO | disclosed |
| CN-101437820-A | Heterobicyclic pyrazole compounds and methods of use | ARRAY BIOPHARMA INC (US) | 2009-05-20 | — | — | CN | disclosed |
| CN-1711243-A | 2-pyridone derivatives as inhibitors of neutrophil elastase | ASTRAZENECA AB (SE) | 2005-12-21 | — | — | CN | disclosed |
| JP-H11100370-A | PRODUCTION OF OPTICALLY ACTIVE PIPERAZINE-2-CARBOXYLIC ACID DERIVATIVE | NICHIJUN KAGAKU KK | 1999-04-13 | — | — | JP | disclosed |
| US-5886181-A | ASYMMETRIC HYDROGENATION OF THE CORRESPONDING 1,4,5,6-TETRAHYDROPYRAZINES | LONZA, LTD. (CH) | 1999-03-23 | — | — | US | disclosed |