Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PLA2G4A | P47712 | 9/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9191040 | 0.79 | KMT2A (0.57) | KMT2APLA2G4ANTSR1 | |
| SCHEMBL10203425 | 0.74 | HTR2A (0.51) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL5537950 | 0.70 | KMT2A (0.60) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL16234644 | 0.70 | HTR2A (0.54) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL27602809 | 0.69 | KDM4E (0.53) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL25146817 | 0.69 | KMT2A (0.54) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL20488791 | 0.68 | HTR6 (0.69) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL12320222 | 0.68 | KMT2A (0.57) | KMT2APLA2G4ANTSR1 | |
| SCHEMBL3268572 | 0.67 | OXER1 (0.44) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL10165388 | 0.67 | HTR2A (0.50) | HDAC3HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3589618-B1 | PYRAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2022-12-28 | — | — | EP | disclosed |