Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | PPARD | Q03181 | 7/20 | 0.49 |
| ▸ | PPARA | Q07869 | 6/20 | 0.49 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | NTSR1 | P30989 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12320222 | 0.84 | KMT2A (0.57) | KMT2APPARDPPARAPPARGNTSR1 | |
| SCHEMBL418013 | 0.81 | KMT2A (0.60) | KMT2APPARDPPARAPPARGNTSR1 | |
| SCHEMBL24797740 | 0.79 | HDAC3 (0.44) | KMT2ANTSR1PLA2G4A | |
| SCHEMBL4234811 | 0.79 | KMT2A (0.62) | KMT2APPARDPPARAPPARGNTSR1 | |
| SCHEMBL30103437 | 0.79 | KMT2A (0.62) | KMT2APPARDPPARAPPARGNTSR1 | |
| SCHEMBL28607801 | 0.78 | KMT2A (0.60) | KMT2APPARDPPARAPPARGITGB3 | |
| SCHEMBL1576340 | 0.78 | KMT2A (0.60) | KMT2APPARDPPARAPPARG | |
| SCHEMBL5537950 | 0.78 | KMT2A (0.60) | KMT2APPARDPPARAPPARGNTSR1 | |
| SCHEMBL19145535 | 0.78 | KMT2A (0.60) | KMT2APPARDPPARAPPARGNTSR1 | |
| SCHEMBL9702533 | 0.78 | KMT2A (0.60) | KMT2APPARDPPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0554313-B1 | DISUBSTITUTED ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY | RHONE POULENC RORER INT (US) | 1995-08-09 | — | — | EP | disclosed |
| EP-0554313-A4 | DISUBSTITUTED ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY | RHONE POULENC RORER INT (US) | 1994-05-18 | — | — | EP | disclosed |
| EP-0554313-A1 | DISUBSTITUTED ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY. | RHONE POULENC RORER INT (US) | 1993-08-11 | — | — | EP | disclosed |
| US-5210208-A | DISUBSTITUTED ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1993-05-11 | — | — | US | disclosed |
| WO-1992005145-A1 | DISUBSTITUTED ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1992-04-02 | — | — | WO | disclosed |