Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 4/20 | 0.42 |
| ▸ | PPARA | Q07869 | 4/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 3/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10716531 | 0.79 | NOTUM (0.51) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL12320222 | 0.79 | KMT2A (0.57) | MAPTAKR1C3AKR1C2KMT2APPARD | |
| SCHEMBL5094204 | 0.78 | KDM4E (0.58) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL4228624 | 0.77 | KDM4E (0.47) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL9191040 | 0.76 | KMT2A (0.57) | KMT2APPARDPPARAPPARGNTSR1 | |
| SCHEMBL4233570 | 0.75 | ALDH1A1 (0.50) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL27872943 | 0.74 | KMT2A (0.41) | KDM4EALDH1A1KMT2AHDAC8HDAC6 | |
| SCHEMBL4240678 | 0.74 | ESRRG (0.50) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL20424510 | 0.74 | KDM4E (0.44) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL28143318 | 0.73 | HTR2A (0.58) | KMT2ANTSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101531631-A | Substituted pyridinones as modulators of p38 map kinase | PHARMACIA CORP (US) | 2009-09-16 | — | — | CN | disclosed |
| CN-100486576-C | Substituted pyridones as modulators of P38MAP kinase | PHARMACIA CORP (US) | 2009-05-13 | — | — | CN | disclosed |
| CN-1646125-A | Substituted pyridones as modulators of P38MAP kinase | PHARMACIA CORP (US) | 2005-07-27 | — | — | CN | disclosed |