Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25408185 | 0.77 | ADORA2A (0.42) | BAZ2BL3MBTL1MEN1KMT2ARXFP1 | |
| SCHEMBL23185591 | 0.77 | BRD4 (0.78) | BRD4 | |
| SCHEMBL25406706 | 0.75 | SPPL2A (0.43) | BAZ2BL3MBTL1MEN1KMT2ARXFP1 | |
| SCHEMBL26039613 | 0.72 | TGFBR1 (0.39) | BAZ2BL3MBTL1BRD4MEN1KMT2A | |
| SCHEMBL18904958 | 0.71 | BAZ2B (0.53) | BAZ2BL3MBTL1BRD4MEN1KMT2A | |
| SCHEMBL12725678 | 0.71 | PHGDH (0.49) | MAPTALDH1A1KDM4EHDAC3HDAC4 | |
| SCHEMBL26852558 | 0.70 | MAPK14 (0.43) | BAZ2BL3MBTL1LMNAKDM4EHDAC3 | |
| SCHEMBL8568625 | 0.69 | BAZ2B (1.00) | BAZ2BL3MBTL1BRD4MEN1KMT2A | |
| SCHEMBL14189821 | 0.68 | BAZ2B (0.67) | BAZ2BBRD4MEN1KMT2ARXFP1 | |
| SCHEMBL1311811 | 0.68 | L3MBTL1 (0.43) | BAZ2BL3MBTL1MEN1KMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3589618-B1 | PYRAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2022-12-28 | — | — | EP | disclosed |