Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYCR1 | P32322 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23419206 | 0.82 | PYCR1 (0.50) | PYCR1MAPTALDH1A1POLBGPR55 | |
| SCHEMBL24649608 | 0.80 | HRH3 (0.55) | PYCR1MAPTKCNH2HRH3 | |
| SCHEMBL20428088 | 0.75 | HTR1A (0.45) | MAPTALDH1A1POLBGPR55THRB | |
| SCHEMBL14174917 | 0.75 | PYCR1 (0.51) | PYCR1MAPTALDH1A1POLBGPR55 | |
| SCHEMBL12802092 | 0.73 | PYCR1 (0.39) | PYCR1MAPTALDH1A1GAASLC6A4 | |
| SCHEMBL14224544 | 0.72 | ALDH1A1 (0.48) | PYCR1MAPTALDH1A1POLBGPR55 | |
| SCHEMBL20428092 | 0.71 | MAPT (0.51) | MAPTALDH1A1POLBGPR55THRB | |
| SCHEMBL12802432 | 0.70 | TLR8 (0.40) | PYCR1MAPTALDH1A1GAASLC6A4 | |
| SCHEMBL24344912 | 0.70 | TSHR (0.50) | ALDH1A1POLBHRH3 | |
| SCHEMBL10899219 | 0.69 | GAA (0.44) | PYCR1MAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464277-B1 | PEGYLATED CARFILZOMIB COMPOUNDS | AMGEN INC (US) | 2022-12-28 | — | — | EP | disclosed |