Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL677962 | 0.78 | KDM4E (1.00) | KDM4EGAACA2ALDH1A1HTT | |
| SCHEMBL678985 | 0.77 | CA2 (1.00) | KDM4ECA2EPHX2NR1H4 | |
| SCHEMBL7230840 | 0.68 | MEN1 (0.65) | KDM4EGAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL29805501 | 0.67 | KDM4E (0.60) | KDM4EGAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL25433246 | 0.66 | KDM4E (0.73) | KDM4EGAACA2ALDH1A1HTT | |
| SCHEMBL678099 | 0.65 | CA2 (0.70) | KDM4ECA2EPHX2NR1H4 | |
| SCHEMBL677539 | 0.65 | CA2 (0.70) | KDM4ECA2EPHX2NR1H4 | |
| SCHEMBL29758010 | 0.64 | SMN1; SMN2 (0.67) | KDM4EGAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL23466602 | 0.64 | SMN1; SMN2 (0.67) | KDM4EGAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL1972790 | 0.63 | MAPT (0.71) | ALDH1A1SMN1; SMN2L3MBTL1HPGDCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2377530-A2 | Modulation of neurogenesis by PDE inhibition | Braincells, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |