Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 3/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL25389334 | 0.85 | TAAR1 (0.38) | — | |
| SCHEMBL22827426 | 0.83 | PDK2 (0.37) | — | |
| SCHEMBL21132537 | 0.73 | KRAS (0.34) | — | |
| SCHEMBL24343563 | 0.73 | — | — | |
| SCHEMBL24802168 | 0.72 | SOS1 (0.36) | — | |
| SCHEMBL28798525 | 0.70 | SOS1 (0.39) | PNMT | |
| SCHEMBL22234725 | 0.70 | PARP1 (0.49) | OPRM1 | |
| SCHEMBL21132431 | 0.70 | SOS1 (0.39) | PNMT | |
| SCHEMBL23344916 | 0.69 | SOS1 (0.41) | — | |
| SCHEMBL23995719 | 0.69 | PTGS2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023098825-A1 | SOS1 INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF | 勤浩医药（苏州）有限公司 | 2023-06-08 | — | — | WO | disclosed |
| WO-2022271679-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-12-29 | — | — | WO | disclosed |