Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CTSG | P08311 | 1/20 | 0.40 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14994677 | 0.75 | ELANE (0.46) | ELANELMNAALOX12MAPK1HSD11B1 | |
| SCHEMBL21763648 | 0.73 | GSK3A (0.45) | LMNAALOX12MAPK1GAAEHMT2 | |
| SCHEMBL16598575 | 0.72 | ELANE (0.50) | ELANEGAAKMT2AMEN1CTSG | |
| SCHEMBL11095312 | 0.72 | KMT2A (0.31) | GAAKMT2A | |
| SCHEMBL19370604 | 0.71 | LMNA (0.52) | ELANELMNAALOX12MAPK1GAA | |
| SCHEMBL7906136 | 0.71 | HTR2C (0.46) | LMNAALOX12MAPK1EHMT2BRD4 | |
| SCHEMBL11093506 | 0.70 | OPRL1 (0.47) | ELANEHSD11B1GAAEHMT2KMT2A | |
| SCHEMBL11093502 | 0.70 | OPRL1 (0.47) | ELANEHSD11B1GAAEHMT2KMT2A | |
| SCHEMBL24801996 | 0.70 | MAPT (0.44) | LMNAALOX12MAPK1GAAKMT2A | |
| SCHEMBL24802004 | 0.70 | MAPT (0.44) | LMNAALOX12MAPK1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022269508-A1 | PYRAZOLYL DERIVATIVES AS INHIBITORS OF THE KRAS MUTANT PROTEIN | NOVARTIS AG (CH) | 2022-12-29 | — | — | WO | disclosed |