Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24802443 | 0.82 | POLB (0.48) | POLBHPGDECE2SMN1; SMN2MEN1 | |
| SCHEMBL24802437 | 0.72 | GAA (0.35) | HPGDGRIN2BGAA | |
| SCHEMBL25795552 | 0.71 | NOS3 (0.39) | HPGDSMN1; SMN2KMT2AALDH1A1GAA | |
| SCHEMBL17868771 | 0.69 | KMT2A (0.58) | POLBHPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL24804840 | 0.67 | GAA (0.44) | POLBHPGDECE2SMN1; SMN2ALDH1A1 | |
| SCHEMBL12987867 | 0.67 | POLB (0.47) | POLBHPGDECE2SMN1; SMN2MEN1 | |
| SCHEMBL30148645 | 0.66 | POLB (0.40) | POLBHPGDECE2SMN1; SMN2MEN1 | |
| SCHEMBL17572089 | 0.66 | MEN1 (0.69) | POLBHPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL1072706 | 0.66 | KMT2A (0.56) | POLBHPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL22800924 | 0.66 | MEN1 (0.50) | POLBSMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022268209-A1 | DERIVATIVE HAVING PYRIMIDINE-FUSED CYCLIC STRUCTURE, AND USE THEREOF | 四川汇宇制药股份有限公司 | 2022-12-29 | — | — | WO | disclosed |