Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | PRKCA | P17252 | 4/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.33 |
| ▸ | PRKCG | P05129 | 3/20 | 0.33 |
| ▸ | PRKCB | P05771 | 3/20 | 0.33 |
| ▸ | PRKCH | P24723 | 3/20 | 0.33 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.33 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.33 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL52102 | 1.00 | POLB (0.42) | POLBPRKCAPRKD3PRKCGPRKCB | |
| SCHEMBL8220668 | 1.00 | POLB (0.42) | POLBPRKCAPRKD3PRKCGPRKCB | |
| SCHEMBL7893349 | 1.00 | POLB (0.42) | POLBPRKCAPRKD3PRKCGPRKCB | |
| SCHEMBL1333553 | 1.00 | POLB (0.42) | POLBPRKCAPRKD3PRKCGPRKCB | |
| SCHEMBL12546111 | 0.87 | POLB (0.37) | POLBPRKCAPRKD3PRKCGPRKCB | |
| SCHEMBL18219141 | 0.87 | POLB (0.37) | POLBPRKCAPRKD3PRKCGPRKCB | |
| SCHEMBL15457672 | 0.87 | POLB (0.37) | POLBPRKCAPRKD3PRKCGPRKCB | |
| SCHEMBL10777104 | 0.80 | POLB (0.40) | POLBPRKCAPRKD3PRKCGPRKCB | |
| SCHEMBL20799266 | 0.79 | PRKCA (0.41) | PRKCAPRKD3PRKCGPRKCBPRKCH | |
| Aceglatone SCHEMBL8852 | 0.76 | POLB (0.39) | POLBPRKCAPRKD3PRKCGPRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373634-A1 | MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS | Mochida Pharmaceutical Co., Ltd. (JP) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010065717-A1 | MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2010-06-10 | — | — | WO | disclosed |