Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR3 | O60755 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 7/20 | 0.42 |
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11596041 | 0.85 | RAB9A (0.43) | GALR3HTTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL31029422 | 0.80 | SMN1; SMN2 (0.42) | HTTRAB9ASMN1; SMN2KDM4EKMT2A | |
| SCHEMBL25057478 | 0.80 | SMN1; SMN2 (0.42) | HTTRAB9ASMN1; SMN2KDM4EKMT2A | |
| SCHEMBL21138784 | 0.79 | GALR3 (0.56) | GALR3RAB9ASMN1; SMN2TP53HSD17B10 | |
| SCHEMBL766829 | 0.78 | GALR3 (0.49) | GALR3HTTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL28505552 | 0.77 | SMN1; SMN2 (0.40) | HTTRAB9ASMN1; SMN2KDM4EKMT2A | |
| SCHEMBL21138493 | 0.76 | EGFR (0.53) | GALR3 | |
| SCHEMBL31277798 | 0.75 | RAB9A (0.46) | GALR3HTTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL19941773 | 0.75 | RAB9A (0.46) | GALR3HTTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL6078615 | 0.75 | KDM4C (0.40) | GALR3HTTRAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114573586-B | Polycyclic compound for inhibiting Bruton tyrosine kinase activity, pharmaceutical composition and application thereof | 杭州和正医药有限公司 | 2023-11-03 | — | — | CN | disclosed |
| WO-2022171191-A1 | COMPOUNDS AS ANTICANCER AGENTS | JINGRUI BIOPHARMA CO., LTD. (CN) | 2022-08-18 | — | — | WO | disclosed |
| CN-114573586-A | Polycyclic compound for inhibiting Bruton's tyrosine kinase activity, pharmaceutical composition and application thereof | 杭州和正医药有限公司 | 2022-06-03 | — | — | CN | disclosed |
| EP-2373163-B1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | GENENTECH INC (US) | 2015-06-10 | — | — | EP | disclosed |
| EP-2373163-B1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | GENENTECH INC (US) | 2015-06-10 | — | — | EP | disclosed |
| US-8232273-B2 | Heterocyclic compounds and methods of use | GENENTECH, INC. (US) | 2012-07-31 | — | — | US | disclosed |
| US-8232273-B2 | Heterocyclic compounds and methods of use | GENENTECH, INC. (US) | 2012-07-31 | — | — | US | disclosed |
| US-8232273-B2 | Heterocyclic compounds and methods of use | GENENTECH, INC. (US) | 2012-07-31 | — | — | US | disclosed |
| EP-2373163-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-10-12 | — | — | EP | disclosed |
| US-20100210622-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | ABBVIE INC. | 2010-08-19 | — | — | US | disclosed |
| US-20100210622-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | ABBVIE INC. | 2010-08-19 | — | — | US | disclosed |
| US-20100210622-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | ABBVIE INC. | 2010-08-19 | — | — | US | disclosed |
| WO-2010080503-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-07-15 | — | — | WO | disclosed |
| WO-2010080503-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-07-15 | — | — | WO | disclosed |
| US-7517888-B2 | e.g. cyclopentyl(9-ethyl-8-phenylpurin-6-yl)amine; diuretic; heart failure, chronic renal disease, cirrhosis | CV THERAPEUTICS, INC. (US) | 2009-04-14 | — | — | US | disclosed |
| EP-1751159-A2 | PURINE DERIVATIVES AS A1 ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS, INC. (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005105803-A2 | PURINE DERIVATIVES AS A1 ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS, INC. (US) | 2005-11-10 | — | — | WO | disclosed |
| US-20050245546-A1 | A1 adenosine receptor antagonists | CV THERAPEUTICS, INC. | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210622-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | BCL2A1, BAX, BCL2 | GALR3 3864/4885HTT 2623/4885RAB9A 2893/4885 |
| US-20050245546-A1 | A1 adenosine receptor antagonists | ADORA1, ADORA2A, ADORA3 | GALR3 639/4885HTT 2440/4885RAB9A 1681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.