Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.53 |
| ▸ | LTA4H | P09960 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL378659 | 1.00 | KCNH2 (0.55) | KCNH2DRD2DRD4DRD3MAPT | |
| SCHEMBL22609255 | 0.92 | KCNH2 (0.56) | KCNH2DRD2DRD4DRD3MAPT | |
| SCHEMBL519168 | 0.91 | DRD2 (0.58) | KCNH2DRD2DRD4DRD3MAPT | |
| SCHEMBL31493409 | 0.90 | ALDH1A1 (0.56) | KCNH2DRD2DRD4DRD3MAPT | |
| SCHEMBL4937120 | 0.89 | HRH3 (0.57) | KCNH2DRD2DRD4DRD3MAPT | |
| SCHEMBL6228523 | 0.88 | MAPT (0.65) | KCNH2DRD2DRD4DRD3MAPT | |
| SCHEMBL28180194 | 0.87 | HRH3 (0.60) | KCNH2DRD2DRD4DRD3MAPT | |
| SCHEMBL28180989 | 0.87 | HRH3 (0.60) | KCNH2DRD2DRD4DRD3MAPT | |
| SCHEMBL28180977 | 0.87 | HRH3 (0.60) | KCNH2DRD2DRD4DRD3MAPT | |
| SCHEMBL17971426 | 0.87 | HRH3 (0.60) | KCNH2DRD2DRD4DRD3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563789-A1 | 7-(1H-PYRAZOL-4-YL)-1,6-NAPHTHYRIDINE COMPOUNDS AS SYK INHIBITORS | Glaxo Group Limited (GB) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011134971-A1 | 7-(1H-PYRAZOL-4-YL)-1,6-NAPHTHYRIDINE COMPOUNDS AS SYK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-11-03 | — | — | WO | disclosed |
| EP-2376481-A1 | PYRIMIDINECARBOXAMIDE DERIVATIVES AS INHIBITORS OF SYK KINASE | Glaxo Group Limited (GB) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010097248-A1 | PYRIMIDINECARBOXAMIDE DERIVATIVES AS INHIBITORS OF SYK KINASE | GLAXO GROUP LIMITED (GB) | 2010-09-02 | — | — | WO | disclosed |