Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16014263 | 0.87 | DGAT1 (0.43) | DGAT1NPC1DYRK1A | |
| SCHEMBL30084147 | 0.86 | NPC1 (0.34) | DGAT1MAPK14NAMPTNPC1MAPT | |
| SCHEMBL3515565 | 0.86 | NPC1 (0.34) | DGAT1MAPK14NAMPTNPC1MAPT | |
| SCHEMBL17432551 | 0.86 | DGAT1 (0.39) | DGAT1NPC1MAPTDYRK1A | |
| SCHEMBL14493396 | 0.85 | MKNK1 (0.41) | MAPK14KMT2ANPC1MAPTALDH1A1 | |
| SCHEMBL3515950 | 0.82 | L3MBTL1 (0.47) | NPC1MAPT | |
| SCHEMBL23783005 | 0.81 | DGAT1 (0.40) | DGAT1KMT2ANAMPTNPC1CYP3A4 | |
| SCHEMBL757561 | 0.81 | DGAT1 (0.38) | DGAT1KMT2ANPC1MAPTALDH1A1 | |
| SCHEMBL16024590 | 0.81 | DGAT1 (0.38) | DGAT1MAPK14 | |
| SCHEMBL30084198 | 0.81 | MAPT (0.37) | MAPK14KMT2ANAMPTNPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022271840-A1 | SELECTIVE INDAZOLE LRRK2 INHIBITORS AND METHODS FOR USE THEREOF | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2022-12-29 | — | — | WO | disclosed |
| WO-2022271840-A1 | SELECTIVE INDAZOLE LRRK2 INHIBITORS AND METHODS FOR USE THEREOF | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2022-12-29 | — | — | WO | disclosed |