Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UPP1 | Q16831 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | GAPDH | P04406 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2480913 | 1.00 | UPP1 (0.47) | UPP1HPGDALDH1A1CHRNB2CHRNA5 | |
| SCHEMBL2480919 | 1.00 | UPP1 (0.47) | UPP1HPGDALDH1A1CHRNB2CHRNA5 | |
| SCHEMBL2481853 | 0.88 | UPP1 (0.47) | UPP1HPGDALDH1A1CHRNB2CHRNA5 | |
| SCHEMBL13021363 | 0.88 | ALDH1A1 (0.50) | HPGDALDH1A1CHRNB2CHRNA5CHRNA7 | |
| SCHEMBL930473 | 0.88 | ALDH1A1 (0.50) | HPGDALDH1A1CHRNB2CHRNA5CHRNA7 | |
| SCHEMBL24371811 | 0.88 | ALDH1A1 (0.50) | HPGDALDH1A1CHRNB2CHRNA5CHRNA7 | |
| SCHEMBL12482663 | 0.88 | ALDH1A1 (0.50) | HPGDALDH1A1CHRNB2CHRNA5CHRNA7 | |
| SCHEMBL15304485 | 0.88 | ALDH1A1 (0.50) | HPGDALDH1A1CHRNB2CHRNA5CHRNA7 | |
| SCHEMBL16576338 | 0.88 | ALDH1A1 (0.50) | HPGDALDH1A1CHRNB2CHRNA5CHRNA7 | |
| SCHEMBL5679345 | 0.80 | UPP1 (0.47) | UPP1HPGDALDH1A1CHRNB2CHRNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045520-B2 | Synthesis of purine nucleosides | GILEAD PHARMASSET LLC (US) | 2015-06-02 | — | — | US | disclosed |
| US-8716263-B2 | Synthesis of purine nucleosides | GILEAD PHARMASSET LLC (US) | 2014-05-06 | — | — | US | disclosed |
| EP-2671888-A1 | 3',5'-cyclic nucleoside phosphate analogues | Gilead Pharmasset LLC (US) | 2013-12-11 | — | — | EP | disclosed |
| US-20120316327-A1 | SYNTHESIS OF PURINE NUCLEOSIDES | GILEAD PHARMASSET LLC (US) | 2012-12-13 | — | — | US | disclosed |
| EP-2376515-A1 | Synthesis of purine nucleosides | Pharmasset, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| US-20100279973-A1 | SYNTHESIS OF PURINE NUCLEOSIDES | PHARMASSET, INC. (US) | 2010-11-04 | — | — | US | disclosed |
| WO-2010075554-A1 | SYNTHESIS OF PURINE NUCLEOSIDES | PHARMASSET, INC. (US) | 2010-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100279973-A1 | SYNTHESIS OF PURINE NUCLEOSIDES | PNP, NUDT1, TYMP | UPP1 29/4885HPGD 476/4885ALDH1A1 2131/4885 |
| US-20120316327-A1 | SYNTHESIS OF PURINE NUCLEOSIDES | PNP, NUDT1, TYMP | UPP1 29/4885HPGD 476/4885ALDH1A1 2131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.