Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19085534 | 1.00 | LMNA (0.33) | LMNATSHRALDH1A1TDP1L3MBTL1 | |
| SCHEMBL15133317 | 1.00 | LMNA (0.33) | LMNATSHRALDH1A1TDP1L3MBTL1 | |
| SCHEMBL14887480 | 0.83 | TSHR (0.46) | LMNATSHRTDP1 | |
| SCHEMBL16579815 | 0.82 | — | — | |
| SCHEMBL6422381 | 0.82 | — | — | |
| SCHEMBL12774646 | 0.79 | THRB (0.48) | LMNAALDH1A1 | |
| SCHEMBL1076490 | 0.78 | TSHR (0.33) | LMNATSHRALDH1A1TDP1 | |
| SCHEMBL12295744 | 0.77 | PRKCA (0.31) | — | |
| SCHEMBL1104257 | 0.73 | SLC22A6 (0.42) | LMNATDP1 | |
| SCHEMBL15704525 | 0.72 | TSHR (0.40) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370438-A1 | IMIDAZO [1,2A]PYRIDINE DERIVATIVES, THEIR USE AS S1P1 AGONISTS AND METHODS FOR THEIR PRODUCTION | Exelixis, Inc. (US) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010065760-A1 | IMIDAZO [1,2A] PYRIDINE DERIVATIVES, THEIR USE AS S1P1 AGONISTS AND METHODS FOR THEIR PRODUCTION | EXELIXIS, INC. (US) | 2010-06-10 | — | — | WO | disclosed |