Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22861471 | 0.98 | NPC1 (0.40) | HPGDNPC1TP53RAB9ATHRA | |
| SCHEMBL24925935 | 0.92 | HPGD (0.39) | HPGDNPC1TP53RAB9ATHRA | |
| SCHEMBL20333177 | 0.92 | NPC1 (0.42) | HPGDNPC1TP53RAB9ATHRA | |
| SCHEMBL22890957 | 0.88 | USP2 (0.33) | HPGDNPC1TP53RAB9AUSP2 | |
| SCHEMBL22861369 | 0.87 | USP2 (0.42) | HPGDNPC1TP53RAB9ATHRA | |
| SCHEMBL20356813 | 0.85 | USP2 (0.37) | HPGDNPC1TP53RAB9ATHRA | |
| SCHEMBL27667664 | 0.85 | GNAI3 (0.40) | HPGDNPC1TP53RAB9ATHRA | |
| SCHEMBL21566510 | 0.84 | ALDH1A1 (0.47) | THRATHRBUSP2ALDH1A1 | |
| SCHEMBL24641404 | 0.84 | THRA (0.39) | HPGDNPC1TP53RAB9ATHRA | |
| SCHEMBL21348141 | 0.83 | THRA (0.39) | HPGDNPC1TP53RAB9ATHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220411388-A1 | SUBSTITUTED IMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | BIAL R&D INVEST S A (PT) | 2022-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220411388-A1 | SUBSTITUTED IMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | GBA1, GAA, CLN6 | HPGD 1683/4885NPC1 41/4885TP53 1076/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.