Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SCN4A | P35499 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | CCR4 | P51679 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13291656 | 0.88 | SCN4A (0.50) | KDM4EMAPK1SMN1; SMN2SCN4AALDH1A1 | |
| SCHEMBL16005382 | 0.88 | SCN4A (0.50) | KDM4EMAPK1SMN1; SMN2SCN4AALDH1A1 | |
| SCHEMBL20564634 | 0.80 | DRD2 (0.36) | — | |
| SCHEMBL20723740 | 0.77 | DRD2 (0.30) | — | |
| SCHEMBL20723743 | 0.77 | DRD2 (0.30) | — | |
| SCHEMBL587951 | 0.74 | BTK (0.40) | KMT2AEPHX2GAA | |
| SCHEMBL29975603 | 0.74 | SLC22A12 (0.33) | EPHX2POLB | |
| SCHEMBL16843297 | 0.74 | DRD2 (0.38) | — | |
| SCHEMBL12302296 | 0.73 | KMT2A (0.49) | KDM4ESMN1; SMN2SCN4AALDH1A1KMT2A | |
| SCHEMBL19947130 | 0.73 | CDK9 (0.38) | SMN1; SMN2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373168-A1 | INHIBITORS OF HCV NS5A | Presidio Pharmaceuticals, Inc. (US) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010065681-A1 | INHIBITORS OF HCV NS5A | PRESIDIO PHARMACEUTICALS, INC. (US) | 2010-06-10 | — | — | WO | disclosed |