SCHEMBL24813187

SCHEMBL24813187

NNc1nc(N2CCOCc3c(Br)cccc32)c2c(F)c(F)ccc2n1

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AKT1 P31749 2/20 0.34
LRRK2 Q5S007 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23576881 0.90 ACHE (0.34) AKT1LRRK2
SCHEMBL29909109 0.90 ACHE (0.34) AKT1LRRK2
SCHEMBL24813570 0.87 ACHE (0.33)
SCHEMBL30047978 0.87 ACHE (0.33)
SCHEMBL24815233 0.86 ACHE (0.34)
SCHEMBL24813185 0.85 AKT1 (0.35) AKT1LRRK2
SCHEMBL24816017 0.84 MAPK1 (0.36)
SCHEMBL24815926 0.78 ACHE (0.33) LRRK2
SCHEMBL24813174 0.77 ACHE (0.41)
SCHEMBL29909500 0.76 ACHE (0.43)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4359415-A1 DIACYLGLYERCOL KINASE MODULATING COMPOUNDS GILEAD SCIENCES, INC. (US) 2024-05-01 EP disclosed
WO-2022271684-A1 DIACYLGLYERCOL KINASE MODULATING COMPOUNDS GILEAD SCIENCES, INC. (US) 2022-12-29 WO disclosed
WO-2022271684-A1 DIACYLGLYERCOL KINASE MODULATING COMPOUNDS GILEAD SCIENCES, INC. (US) 2022-12-29 WO disclosed