Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of 1-Naphthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | NQO2 | P16083 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1-Naphthol SCHEMBL29039781 | 0.91 | CYP1A2 (0.71) | CYP1A2HSD17B10CYP2C9CYP2C19PTPN22 | |
| 1-Naphthol SCHEMBL27983786 | 0.89 | CYP1A2 (0.74) | CYP1A2HSD17B10CYP2C9CYP2C19PTPN22 | |
| 1-Naphthol SCHEMBL28476693 | 0.89 | CYP1A2 (0.74) | CYP1A2HSD17B10CYP2C9CYP2C19PTPN22 | |
| 1-Naphthol SCHEMBL10627914 | 0.88 | CYP1A2 (0.90) | CYP1A2HSD17B10CYP2C9CYP2C19PTPN22 | |
| 1-Naphthol SCHEMBL10486461 | 0.88 | CYP1A2 (1.00) | CYP1A2HSD17B10CYP2C9CYP2C19PTPN22 | |
| 1-Naphthol SCHEMBL29767730 | 0.88 | CYP1A2 (1.00) | CYP1A2HSD17B10CYP2C9CYP2C19PTPN22 | |
| 1-Naphthol SCHEMBL3416 | 0.88 | CYP1A2 (1.00) | CYP1A2HSD17B10CYP2C9CYP2C19PTPN22 | |
| 1-Naphthol SCHEMBL273260 | 0.88 | CYP1A2 (1.00) | CYP1A2HSD17B10CYP2C9CYP2C19PTPN22 | |
| 1-Naphthol SCHEMBL5336584 | 0.86 | CYP1A2 (0.85) | CYP1A2HSD17B10CYP2C9CYP2C19PTPN22 | |
| 1-Naphthol SCHEMBL11247168 | 0.85 | CYP1A2 (0.94) | CYP1A2HSD17B10CYP2C9CYP2C19PTPN22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117564289-B | Iridium ruthenium gold core-shell structure nano material and preparation method and application thereof | 中国科学技术大学 | 2024-05-17 | — | — | CN | claimed |
| CN-115015342-B | Preparation method of metal ion doped boron nano-sheet compound used as exosome ratio electrochemical aptamer sensor | 青岛大学 | 2024-02-23 | — | — | CN | claimed |
| CN-117564289-A | Iridium ruthenium gold core-shell structure nano material and preparation method and application thereof | 中国科学技术大学 | 2024-02-20 | — | — | CN | claimed |
| CN-117143759-A | Separation and identification method for bacillus tropicalis and application thereof | 韶关学院 | 2023-12-01 | — | — | CN | claimed |
| CN-114019001-B | MOF/ZnO composite material and preparation method and application of working electrode thereof | 石河子大学 | 2023-10-27 | — | — | CN | claimed |
| CN-116410482-A | Preparation method and application of zirconium-based metal organic framework/reduced graphene oxide composite material and working electrode | 石河子大学 | 2023-07-11 | — | — | CN | claimed |
| CN-115015342-A | Preparation method of electrochemical aptamer sensor using metal ion doped boron nanosheet composite as exosome ratio | 青岛大学 | 2022-09-06 | — | — | CN | claimed |
| CN-114216989-A | Kit for detecting plasma indole substances by high performance liquid chromatography and application thereof | 重庆医科大学国际体外诊断研究院 | 2022-03-22 | — | — | CN | claimed |
| CN-114019001-A | MOF/ZnO composite material and preparation method and application of working electrode thereof | 石河子大学 | 2022-02-08 | — | — | CN | claimed |
| CN-113336257-A | Copper oxide/graphene composite nanomaterial, preparation method thereof and bifunctional electrode for COD detection and removal | 深圳瀚光科技有限公司 | 2021-09-03 | — | — | CN | claimed |
| CN-110441365-B | Detection method of iron-based spinel for heavy metal ion electrochemical sensor | 石河子大学 | 2021-07-02 | — | — | CN | claimed |
| CN-112326869-A | Method for determining and identifying content of guanidine nitrate | 佛山市南海北沙制药有限公司 | 2021-02-05 | — | — | CN | claimed |
| CN-108226331-B | Detection method of anti-tumor injection preparation | 贵州益佰制药股份有限公司 | 2020-09-22 | — | — | CN | claimed |
| CN-109374709-A | Based on metal-organic framework material-ferroheme electrochemical sensor preparation method and its usage | 扬州大学 | 2019-02-22 | — | — | CN | claimed |
| CN-117564289-B | Iridium ruthenium gold core-shell structure nano material and preparation method and application thereof | 中国科学技术大学 | 2024-05-17 | — | — | CN | disclosed |
| CN-117564289-B | Iridium ruthenium gold core-shell structure nano material and preparation method and application thereof | 中国科学技术大学 | 2024-05-17 | — | — | CN | disclosed |
| CN-117983204-A | Preparation method and application of lignin carbon quantum dot modified bismuth vanadate nanocomposite | 哈尔滨理工大学 | 2024-05-07 | — | — | CN | disclosed |
| CN-1227267-C | Spiruline polyose, its extraction process and it medical application in increasing white cells and treating cancer | UNIV CHINA PHARMA (CN) | 2005-11-16 | — | — | CN | disclosed |
| CN-1397567-A | Spiruline polyose, its extraction process and it medical application in increasing white cells and treating cancer | JIUFANG PHARMACEUTICAL CO LTD (CN) | 2003-02-19 | — | — | CN | disclosed |
| CN-1312297-A | Extraction method of BG polysaccharide as hemostatic material | LU GE (CN) | 2001-09-12 | — | — | CN | disclosed |