Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLOD2 | O00469 | 1/20 | 0.46 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.46 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.44 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.44 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL30444900 | 1.00 | PLOD2 (0.46) | PLOD2PLOD3PLOD1CDK5CDK5R1 | |
| Carbamic Acid SCHEMBL17846525 | 0.86 | F7 (0.57) | PLOD2L3MBTL1ALDH1A1APPGAA | |
| Hydrogen Peroxide SCHEMBL5721864 | 0.84 | — | — | |
| SCHEMBL4855558 | 0.84 | ALDH1A1 (0.44) | PLOD2ALDH1A1APPGAAHCAR3 | |
| Acetic Acid SCHEMBL27980565 | 0.82 | ALDH1A1 (0.50) | PLOD2L3MBTL1ALDH1A1APPGAA | |
| SCHEMBL19628 | 0.79 | — | — | |
| SCHEMBL29455057 | 0.79 | — | — | |
| Fumaric Acid SCHEMBL4346282 | 0.79 | ALDH1A1 (0.56) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Trifluoroacetic Acid SCHEMBL32685343 | 0.79 | L3MBTL1 (0.50) | PLOD2PLOD3PLOD1CDK5CDK5R1 | |
| Trifluoroacetic Acid SCHEMBL28778782 | 0.79 | L3MBTL1 (0.50) | PLOD2PLOD3PLOD1CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110156813-A | Heterocyclic compound as TRK inhibitor | 北京诺诚健华医药科技有限公司 | 2019-08-23 | — | — | CN | disclosed |
| CN-104114553-B | Substituted pyrazolo [1,5 a] pyridine as tropomyosin receptor kinase (Trk) inhibitor | 雷迪博士实验室有限公司 | 2017-03-01 | — | — | CN | disclosed |
| CN-104114553-A | Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (Trk) inhibitors | REDDYS LAB LTD DR | 2014-10-22 | — | — | CN | disclosed |
| CN-102414177-B | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT | 2014-07-02 | — | — | CN | disclosed |
| CN-101495478-B | Imino-imidazo-pyridine derivatives with antithrombotic activity | SANOFI AVENTIS | 2013-03-27 | — | — | CN | disclosed |
| CN-102471339-A | Pyrrolopyridine inhibitors of kinases | ABBOTT LAB | 2012-05-23 | — | — | CN | disclosed |
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |
| CN-101495478-A | Imino-imidazo-pyridine derivatives with antithrombotic activity | SANOFI AVENTIS (FR) | 2009-07-29 | — | — | CN | disclosed |