SCHEMBL24817738

SCHEMBL24817738

O=C1CCC(N2Cc3cc(O[C@H]4C[C@H](N5CCNCC5)C4)ccc3C2=O)C(=O)N1

nearest known ligand 0.58

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 10/20 0.58
▸ IKZF2 Q9UKS7 7/20 0.56
▸ WIZ O95785 3/20 0.47
▸ CSNK1A1 P48729 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20231482 1.00 CRBN (0.58) CRBNIKZF2WIZCSNK1A1
SCHEMBL31333471 0.89 IKZF2 (0.60) CRBNIKZF2WIZCSNK1A1
SCHEMBL20234306 0.87 CRBN (0.65) CRBNIKZF2WIZCSNK1A1
SCHEMBL30273536 0.87 CRBN (0.65) CRBNIKZF2WIZCSNK1A1
SCHEMBL20046231 0.87 CRBN (0.65) CRBNIKZF2WIZCSNK1A1
SCHEMBL31070706 0.85 CRBN (0.60) CRBNIKZF2WIZCSNK1A1
SCHEMBL31718260 0.85 CRBN (0.62) CRBNIKZF2WIZCSNK1A1
SCHEMBL20231488 0.84 CRBN (0.64) CRBNIKZF2WIZCSNK1A1
SCHEMBL23350206 0.84 CRBN (0.64) CRBNIKZF2WIZCSNK1A1
SCHEMBL20231436 0.84 CRBN (0.67) CRBNIKZF2WIZCSNK1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022268229-A1 PROTEIN INHIBITOR OR DEGRADING AGENT, PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PHARMACEUTICAL USE 和径医药科技(上海)有限公司 2022-12-29 — — WO disclosed
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