Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 2/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27988230 | 0.90 | MAPT (0.49) | MAPTKMT2AMEN1SMN1; SMN2SLC6A3 | |
| Phosphine SCHEMBL22345943 | 0.88 | MAPT (0.48) | MAPTKMT2AMEN1SMN1; SMN2SLC6A3 | |
| SCHEMBL11482229 | 0.85 | MAPT (0.51) | MAPTKMT2AMEN1SMN1; SMN2SLC6A3 | |
| SCHEMBL2481945 | 0.84 | MAPT (0.48) | MAPTKMT2AMEN1SMN1; SMN2SLC6A3 | |
| Biphenyl SCHEMBL21880211 | 0.84 | MAPT (0.45) | MAPTKMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL2505165 | 0.83 | KMT2A (0.45) | MAPTKMT2AMEN1SMN1; SMN2SLC6A3 | |
| SCHEMBL2482056 | 0.83 | KMT2A (0.45) | MAPTKMT2AMEN1SMN1; SMN2SLC6A3 | |
| SCHEMBL498389 | 0.83 | MAPT (0.55) | MAPTKMT2AMEN1SMN1; SMN2SLC6A3 | |
| SCHEMBL2480091 | 0.83 | KMT2A (0.48) | MAPTKMT2AMEN1SMN1; SMN2SLC6A3 | |
| SCHEMBL2483534 | 0.83 | KMT2A (0.45) | MAPTKMT2AMEN1SMN1; SMN2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160280808-A1 | Procatalyst Composition With Substituted 1,2-Phenylene Aromatic Diester Internal Donor and Method | W. R. GRACE & CO.-CONN. | 2016-09-29 | — | — | US | disclosed |
| CN-104860826-A | Production of substituted phenylene aromatic diesters | DOW GLOBAL TECHNOLOGIES LLC | 2015-08-26 | — | — | CN | disclosed |
| CN-102741215-B | Production of substituted phenylene aromatic diesters | DOW GLOBAL TECHNOLOGIES INC | 2015-04-29 | — | — | CN | disclosed |
| US-8604235-B2 | Production of substituted phenylene aromatic diesters and compositions | DOW GLOBAL TECHNOLOGIES LLC (US) | 2013-12-10 | — | — | US | disclosed |
| EP-2376423-A1 | PRODUCTION OF SUBSTITUTED PHENYLENE AROMATIC DIESTERS | Dow Global Technologies LLC (US) | 2011-10-19 | — | — | EP | disclosed |
| US-20100204506-A1 | Production of Substituted Phenylene Aromatic Diesters and Compositions | W. R. GRACE & CO.-CONN. | 2010-08-12 | — | — | US | disclosed |
| WO-2010078519-A1 | PRODUCTION OF SUBSTITUTED PHENYLENE AROMATIC DIESTERS | DOW GLOBAL TECHNOLOGIES INC. (US) | 2010-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204506-A1 | Production of Substituted Phenylene Aromatic Diesters and Compositions | PAH, DDC, DDT | MAPT 2384/4885KMT2A 1611/4885MEN1 3036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.