Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30310926 | 1.00 | DYRK1A (0.37) | DYRK1AMAPTRAB9ASMN1; SMN2PRKCI | |
| SCHEMBL30310938 | 0.95 | DYRK1A (0.37) | DYRK1AMAPTRAB9ASMN1; SMN2PRKCI | |
| SCHEMBL24823317 | 0.95 | DYRK1A (0.37) | DYRK1AMAPTRAB9ASMN1; SMN2PRKCI | |
| SCHEMBL30952889 | 0.80 | RAB9A (0.37) | MAPTRAB9ASMN1; SMN2KDM4ENPC1 | |
| SCHEMBL23625903 | 0.80 | RAB9A (0.37) | MAPTRAB9ASMN1; SMN2KDM4ENPC1 | |
| SCHEMBL24823322 | 0.79 | RXFP1 (0.38) | MAPTKDM4E | |
| SCHEMBL30311034 | 0.79 | RXFP1 (0.38) | MAPTKDM4E | |
| SCHEMBL24823325 | 0.77 | — | — | |
| SCHEMBL30310958 | 0.77 | — | — | |
| SCHEMBL30148370 | 0.77 | CYP11B1 (0.39) | MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115843293-A | Tricyclic compound, preparation method and medical application thereof | 中国医药研究开发中心有限公司 | 2023-03-24 | — | — | CN | disclosed |
| WO-2022267930-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 中国医药研究开发中心有限公司 | 2022-12-29 | — | — | WO | disclosed |