Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 6/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23625903 | 1.00 | RAB9A (0.37) | RAB9AALDH1A1MAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL17942752 | 0.81 | ULK1 (0.39) | RAB9AALDH1A1MAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL24823317 | 0.80 | DYRK1A (0.37) | RAB9AMAPTSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL30310926 | 0.80 | DYRK1A (0.37) | RAB9AMAPTSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL24823318 | 0.80 | DYRK1A (0.37) | RAB9AMAPTSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL30310938 | 0.80 | DYRK1A (0.37) | RAB9AMAPTSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL24823307 | 0.79 | PDE10A (0.32) | — | |
| SCHEMBL31391624 | 0.79 | PDE10A (0.32) | — | |
| SCHEMBL30148370 | 0.76 | CYP11B1 (0.39) | KMT2AMEN1TDP1L3MBTL1RXFP1 | |
| SCHEMBL24823325 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113767090-B | Tricyclic compound, preparation method and medical application thereof | 中国医药研究开发中心有限公司 | 2024-05-28 | — | — | CN | disclosed |