Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | SGK1 | O00141 | 1/20 | 0.31 |
| ▸ | APAF1 | O14727 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30041891 | 0.87 | MAPT (0.47) | SMN1; SMN2ALDH1A1MAPTGAAMEN1 | |
| SCHEMBL24824320 | 0.86 | SMN1; SMN2 (0.50) | SMN1; SMN2HPGDALDH1A1NPC1RAB9A | |
| SCHEMBL29481812 | 0.77 | MAPT (0.47) | SMN1; SMN2HPGDALDH1A1MAPTGAA | |
| SCHEMBL3250820 | 0.77 | MAPT (0.47) | SMN1; SMN2HPGDALDH1A1MAPTGAA | |
| SCHEMBL23625921 | 0.77 | MAPT (0.45) | SMN1; SMN2HPGDALDH1A1NPC1RAB9A | |
| SCHEMBL30952913 | 0.77 | MAPT (0.45) | SMN1; SMN2HPGDALDH1A1NPC1RAB9A | |
| SCHEMBL1856539 | 0.74 | SMN1; SMN2 (0.61) | SMN1; SMN2HPGDALDH1A1NPC1RAB9A | |
| SCHEMBL10841800 | 0.74 | MAPT (0.47) | SMN1; SMN2ALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL24823372 | 0.72 | ALDH1A1 (0.34) | SMN1; SMN2HPGDALDH1A1NPC1RAB9A | |
| SCHEMBL30040831 | 0.71 | MAPT (0.55) | SMN1; SMN2MAPTGAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022267930-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 中国医药研究开发中心有限公司 | 2022-12-29 | — | — | WO | disclosed |