Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347754 | 0.80 | PDE3B (0.44) | CYP11B2CYP11B1PDE3BPDE3AGABRA5 | |
| SCHEMBL6619979 | 0.80 | LMNA (0.54) | CYP11B2CYP11B1PDE3BPDE3ALMNA | |
| SCHEMBL1744601 | 0.79 | PDE3B (0.43) | CYP11B2CYP11B1PDE3BPDE3AGABRA5 | |
| SCHEMBL8600208 | 0.79 | CYP11B2 (0.42) | CYP11B2CYP11B1PDE3BPDE3AGABRA5 | |
| SCHEMBL1744896 | 0.78 | CYP11B2 (0.41) | CYP11B2CYP11B1PDE3BPDE3AGABRA5 | |
| SCHEMBL4103368 | 0.77 | HTR1A (0.45) | CYP11B2CYP11B1PDE3BPDE3APTGER3 | |
| SCHEMBL16972829 | 0.76 | CYP11B2 (0.42) | CYP11B2CYP11B1PDE3BPDE3AGABRA5 | |
| SCHEMBL1119872 | 0.74 | PDE3B (0.50) | CYP11B2CYP11B1PDE3BPDE3AHPGD | |
| SCHEMBL20527122 | 0.73 | CYP11B2 (0.48) | CYP11B2CYP11B1PDE3BPDE3AGABRA5 | |
| SCHEMBL20456013 | 0.73 | CYP11B2 (0.51) | CYP11B2CYP11B1PDE3BPDE3AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022267930-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 中国医药研究开发中心有限公司 | 2022-12-29 | — | — | WO | disclosed |