Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 12/20 | 0.69 |
| ▸ | TTR | P02766 | 4/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 2/20 | 0.60 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.60 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.60 |
| ▸ | GMNN | O75496 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | ESR1 | P03372 | 1/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14686073 | 0.86 | KDM4E (0.70) | AKR1C3TTRKDM4ECYP3A4MAPK1 | |
| SCHEMBL14686072 | 0.86 | KDM4E (0.70) | AKR1C3TTRKDM4ECYP3A4MAPK1 | |
| Caffeic Acid SCHEMBL2483116 | 0.83 | TTR (0.72) | AKR1C3TTRKDM4ECYP3A4ALOX15 | |
| Caffeic Acid SCHEMBL2483109 | 0.83 | TTR (0.72) | AKR1C3TTRKDM4ECYP3A4ALOX15 | |
| SCHEMBL7252136 | 0.82 | KDM4E (0.73) | AKR1C3TTRKDM4ECYP3A4ALOX15 | |
| SCHEMBL4621755 | 0.82 | KDM4E (0.73) | AKR1C3TTRKDM4ECYP3A4ALOX15 | |
| Caffeic Acid Phenethyl Ester SCHEMBL38666014 | 0.80 | TTR (0.93) | AKR1C3TTRKDM4ECYP3A4ALOX15 | |
| Ferulate SCHEMBL18167441 | 0.79 | ALOX5 (0.73) | AKR1C3TTRKDM4ECYP3A4ALOX15 | |
| SCHEMBL1449041 | 0.79 | FFAR1 (0.59) | AKR1C3AKR1B10AKR1B1 | |
| SCHEMBL1449039 | 0.79 | FFAR1 (0.59) | AKR1C3AKR1B10AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2377543-A2 | Ophthalmic, pharmaceutical and other healthcare preparations with naturally ocurring plant compounds, extracts and derivatives | Natural Disinfectant Technologies (AN) | 2011-10-19 | — | — | EP | disclosed |
| EP-1865929-A2 | DIINDOLYLMETHANE-BASED COMPOSITIONS AND METHODS OF USE THEREOF FOR PROMOTING ORAL MUCOSAL AND BONE HEALTH | Bioresponse, L.L.C. (US) | 2007-12-19 | — | — | EP | disclosed |
| US-20060264497-A1 | Diindolylmethane-based compositions and methods of use thereof for promoting oral mucosal and bone health | BIORESPONSE, L.L.C. | 2006-11-23 | — | — | US | disclosed |
| WO-2006105196-A2 | DIINDOLYLMETHANE-BASED COMPOSITIONS AND METHODS OF USE THEREOF FOR PROMOTING ORAL MUCOSAL AND BONE HEALTH | BIORESPONSE, L.L.C. (US) | 2006-10-05 | — | — | WO | disclosed |
| EP-1492551-A2 | OPHTHALMIC, PHARMACEUTICAL AND OTHER HEALTHCARE PREPARATIONS WITH NATURALLY OCCURING PLANT COMPOUNDS, EXTRACTS AND DERIVATIVES | Natural Disinfectant Technologies (AN) | 2005-01-05 | — | — | EP | disclosed |
| EP-1492551-A2 | OPHTHALMIC, PHARMACEUTICAL AND OTHER HEALTHCARE PREPARATIONS WITH NATURALLY OCCURING PLANT COMPOUNDS, EXTRACTS AND DERIVATIVES | Natural Disinfectant Technologies (AN) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003086442-A3 | OPHTHALMIC, PHARMACEUTICAL AND OTHER HEALTHCARE PREPARATIONS WITH NATURALLY OCCURING PLANT COMPOUNDS, EXTRACTS AND DERIVATIVES | NATURAL DISINFECTANT TECHNOLOG (NL) | 2004-03-18 | — | — | WO | disclosed |
| WO-2003086442-A2 | OPHTHALMIC, PHARMACEUTICAL AND OTHER HEALTHCARE PREPARATIONS WITH NATURALLY OCCURING PLANT COMPOUNDS, EXTRACTS AND DERIVATIVES | NATURAL DISINFECTANT TECHNOLOGIES (AN) | 2003-10-23 | — | — | WO | disclosed |
| WO-2003086442-A2 | OPHTHALMIC, PHARMACEUTICAL AND OTHER HEALTHCARE PREPARATIONS WITH NATURALLY OCCURING PLANT COMPOUNDS, EXTRACTS AND DERIVATIVES | NATURAL DISINFECTANT TECHNOLOGIES (AN) | 2003-10-23 | — | — | WO | disclosed |
| US-20030086986-A1 | Ophthalmic, pharmaceutical and other healthcare preparations with naturally occurring plant compounds, extracts and derivatives | BRUIJN CHRIS DE (DE) | 2003-05-08 | — | — | US | disclosed |
| US-20030086986-A1 | Ophthalmic, pharmaceutical and other healthcare preparations with naturally occurring plant compounds, extracts and derivatives | BRUIJN CHRIS DE (DE) | 2003-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264497-A1 | Diindolylmethane-based compositions and methods of use thereof for promoting oral mucosal and bone health | HPGDS, IDO1, IDO2 | AKR1C3 3434/4885TTR 4267/4885KDM4E 1103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.