Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 16/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | EDNRB | P24530 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL958583 | 0.78 | PTGDR2 (0.38) | PTGDR2AKR1B1EDNRBEDNRAPOLB | |
| SCHEMBL2483198 | 0.77 | PTGDR2 (0.38) | PTGDR2AKR1B1EDNRBEDNRAPOLB | |
| SCHEMBL4392838 | 0.75 | PTGDR2 (0.62) | PTGDR2 | |
| SCHEMBL11959133 | 0.73 | PTGDR2 (0.48) | PTGDR2 | |
| SCHEMBL2484329 | 0.72 | AKR1B1 (0.53) | PTGDR2AKR1B1 | |
| SCHEMBL2487452 | 0.71 | CASP1 (0.46) | PTGDR2 | |
| SCHEMBL2482727 | 0.69 | ALDH3A1 (0.44) | — | |
| SCHEMBL2484605 | 0.69 | PTGDR2 (0.72) | PTGDR2 | |
| SCHEMBL2483121 | 0.69 | PTGDR2 (0.65) | PTGDR2 | |
| SCHEMBL954381 | 0.68 | PTGDR2 (0.67) | PTGDR2AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891075-B1 | TRICYCLIC SPIRO DERIVATIVES AS CRTH2 MODULATORS | MERCK SERONO SA (CH) | 2011-10-19 | — | — | EP | disclosed |