Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 12/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 6/20 | 0.38 |
| ▸ | EDNRB | P24530 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2685018 | 0.78 | PTGDR2 (0.69) | PTGDR2AKR1B1 | |
| SCHEMBL2484433 | 0.78 | PTGDR2 (0.40) | PTGDR2AKR1B1EDNRBEDNRAPOLB | |
| SCHEMBL954850 | 0.76 | PTGDR2 (0.62) | PTGDR2AKR1B1 | |
| SCHEMBL2483198 | 0.75 | PTGDR2 (0.38) | PTGDR2AKR1B1EDNRBEDNRAPOLB | |
| SCHEMBL10058111 | 0.73 | PTGDR2 (0.47) | PTGDR2AKR1B1 | |
| SCHEMBL2684977 | 0.73 | PTGDR2 (0.74) | PTGDR2AKR1B1 | |
| SCHEMBL954381 | 0.70 | PTGDR2 (0.67) | PTGDR2AKR1B1 | |
| SCHEMBL2483121 | 0.69 | PTGDR2 (0.65) | PTGDR2 | |
| SCHEMBL2482727 | 0.69 | ALDH3A1 (0.44) | ALDH1A1 | |
| SCHEMBL2481296 | 0.67 | PTGDR2 (0.66) | PTGDR2AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011006936-A1 | TRICYCLIC INDOLE-DERIVED SPIRO DERIVATIVES AS CRTH2 MODULATORS | MERCK SERONO S.A. (CH) | 2011-01-20 | — | — | WO | disclosed |