Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29833031 | 0.93 | SLC6A5 (0.61) | SLC6A5MAPK1HTTPAX8ALDH1A1 | |
| SCHEMBL520263 | 0.93 | SLC6A5 (0.61) | SLC6A5MAPK1HTTPAX8ALDH1A1 | |
| SCHEMBL29833266 | 0.86 | MAPT (0.57) | ALDH1A1RAB9ALMNASMN1; SMN2MAPT | |
| SCHEMBL519902 | 0.86 | MAPT (0.57) | ALDH1A1RAB9ALMNASMN1; SMN2MAPT | |
| SCHEMBL29788533 | 0.82 | SLC6A5 (0.64) | SLC6A5MAPK1HTTPAX8ALDH1A1 | |
| SCHEMBL2062084 | 0.82 | SLC6A5 (0.64) | SLC6A5MAPK1HTTPAX8ALDH1A1 | |
| SCHEMBL12528187 | 0.81 | SLC6A5 (0.63) | SLC6A5MAPK1HTTPAX8ALDH1A1 | |
| SCHEMBL10035015 | 0.80 | ALDH1A1 (0.52) | SLC6A5MAPK1HTTPAX8ALDH1A1 | |
| SCHEMBL3252580 | 0.79 | ALDH1A1 (0.63) | MAPK1HTTPAX8ALDH1A1RAB9A | |
| SCHEMBL4865184 | 0.78 | HTR6 (0.62) | MAPK1HTTALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |